Phosphatidylcholine-Sterol O-Acyltransferase

Known as: Phosphatidylcholine Sterol O Acyltransferase, LCAT, Lecithin Acyltransferase 
An enzyme secreted from the liver into the plasma of many mammalian species. It catalyzes the esterification of the hydroxyl group of lipoprotein… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1946-2017
02040608019462016

Papers overview

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Highly Cited
2012
Highly Cited
2012
BACKGROUND Epidemiologically, high-density lipoprotein (HDL) cholesterol levels associate inversely with risk of ischemic… (More)
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Highly Cited
2006
Highly Cited
2006
Genetic deficiency or inhibition of cholesteryl ester transfer protein (CETP) leads to a marked increase in plasma levels of… (More)
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Highly Cited
2004
Highly Cited
2004
In individuals with type 2 diabetes, metabolic syndrome, and the combined dyslipidemia, cardiovascular risk is increased by a… (More)
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Highly Cited
2003
Highly Cited
2003
BACKGROUND Obesity-associated dyslipidemia in humans is associated with increased low-density lipoprotein (LDL) oxidation. Mice… (More)
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Highly Cited
2000
Highly Cited
2000
The terminal step in triglyceride biosynthesis is the esterification of diacylglycerol. To study this reaction in the model… (More)
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Highly Cited
1999
Highly Cited
1999
Expression of human lecithin cholesterol acyltransferase (LCAT) in mice (LCAT-Tg) leads to increased high density lipoprotein… (More)
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Highly Cited
1998
Highly Cited
1998
The enzyme acyl coenzyme A:cholesterol acyltransferase 1 (ACAT1) mediates sterol esterification, a crucial component of… (More)
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Highly Cited
1987
Highly Cited
1987
The transfer of insoluble cholesteryl esters among lipoprotein particles is a vital step in normal cholesterol homeostasis and… (More)
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Highly Cited
1985
Highly Cited
1985
Human plasma apoproteins (apo) A-I and A-IV both activate the enzyme lecithin:cholesterol acyltransferase (EC 2.3.1.43). Lecithin… (More)
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Highly Cited
1976
Highly Cited
1976
The three purified proteins which are required for microsomal stearyl-CoA desaturation, NADH-cytochrome b5 reductase, cytochrome… (More)
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