Phase 0 Trial

Known as: Phase 0, Pre-Clinical Trial 
A clinical trial that uses an investigational agent that is available only in very limited quantities and which has never previously given to humans… (More)
National Institutes of Health

Papers overview

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2010
2010
The PD-driven phase 0 trial is a new form, designed to be a first-in-man study, often of a new agent, conducted to assess drug… (More)
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Highly Cited
2009
Highly Cited
2009
PURPOSE We conducted the first phase 0 clinical trial in oncology of a therapeutic agent under the Exploratory Investigational… (More)
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2009
2009
PURPOSE Ectopic expression of GRM1 in murine melanocytes results in transformation into a form of melanoma, and more than 60% of… (More)
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Highly Cited
2008
Highly Cited
2008
Phase 0 trials are designed primarily to evaluate the pharmacodynamic and/or pharmacokinetic properties of selected… (More)
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2008
2008
PURPOSE The National Cancer Institute has completed a first-in-human clinical pharmacodynamic trial of the targeted agent ABT-888… (More)
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Review
2007
Review
2007
An increase in the number of identified therapeutic cancer targets achieved through recent biomedical research has resulted in… (More)
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2007
2007
The answer to this question depends on how this emerging clinical research model challenges the standard expectations ethics has… (More)
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Highly Cited
2001
Highly Cited
2001
The DEAD box RNA helicase (RH) proteins are homologs involved in diverse cellular functions in all of the organisms from… (More)
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1983
1983
Preovulatory bovine follicles (n = 58) were collected at different times after the onset of standing oestrus when cows would… (More)
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1968
Highly Cited
1968
The effects of diphenylbydantoin (DPH) were studied on isolated, perfused Purkinje fibers over a range of concentrations from lCh… (More)
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