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Electrophysiological effects of bepridil and its quaternary derivative CERM 11888 in closed chest anaesthetized dogs: a comparison with verapamil and diltiazem
1 The electrophysiological effects of bepridil, its quaternary derivative, CERM 11888 (methylpyrrolidinium bromide) (both 2.5 mg kg−1 i.v.) and those of verapamil and diltiazem (0.2 mg kg−1 i.v.)Expand
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STUDIES ON THE BRADYCARDIA INDUCED BY BEPRIDIL
1 Bepridil, a novel active compound for prophylactic treatment of anginal attacks, induced persistent bradycardia and a non‐specific anti‐tachycardial effect, the mechanisms of which wereExpand
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Comparative effects of bepridil, its quaternary derivative CERM 11888 and verapamil on caffeine‐induced contracture in ferret hearts
1 The effects of bepridil, its quaternary derivative: CERM 11888 (methyl‐pyrrolidinium bromide) (10−7‐10−5 M), and verapamil (10−7‐10−6 M) were compared on caffeine‐induced contracture of isolatedExpand
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Protective effect of bepridil against veratrine-induced contracture in rat atria.
In isolated stimulated rat atria, superfusion with veratrine caused a marked contracture (VIC) which was absent in calcium-free medium and which was inhibited by tetrodotoxin (IC50VIC of 1.38Expand
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Electrophysiological effects of Org 7797 in the closed‐chest anaesthetized dog
1 The intravenous electrophysiological effects of a new antifibrillatory agent, Org 7797, were studied in closed chest anaesthetized dogs. Effects of fast sodium and slow calcium‐mediated actionExpand