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Perhexiline

Known as: Piperidine, 2-(2,2-dicyclohexylethyl)-, 2-(2,2-Dicyclohexylethyl)piperidine, Perhexiline [Chemical/Ingredient] 
2-(2,2-Dicyclohexylethyl)piperidine. Coronary vasodilator used especially for angina of effort. It may cause neuropathy and hepatitis.
National Institutes of Health

Papers overview

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2015
2015
Recent genome-wide association studies have revealed that variations near the gene locus encoding the transcription factor Kr… Expand
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2015
2015
OBJECTIVES The aim of this study was to determine whether short-term treatment with perhexiline improves cardiac energetics, left… Expand
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Highly Cited
2010
Highly Cited
2010
Background— Hypertrophic cardiomyopathy patients exhibit myocardial energetic impairment, but a causative role for this energy… Expand
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Highly Cited
2009
Highly Cited
2009
Background Mammalian target of rapamycin complex 1 (mTORC1) is a protein kinase that relays nutrient availability signals to… Expand
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Highly Cited
2005
Highly Cited
2005
Background— Chronic heart failure (CHF) is a major cause of morbidity and mortality that requires a novel approach to therapy… Expand
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Highly Cited
1998
Highly Cited
1998
BACKGROUND & AIMS 4,4'-Diethylaminoethoxyhexestrol (DEAEH), amiodarone, and perhexiline cause steatohepatitis in humans. The… Expand
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Highly Cited
1996
Highly Cited
1996
The mechanism of the anti-anginal effect of perhexiline is unclear but appears to involve a shift in cardiac metabolism from… Expand
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Review
1995
Review
1995
Severe and prolonged impairment of mitochondrial beta-oxidation leads to microvesicular steatosis, and, in severe forms, to liver… Expand
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Highly Cited
1994
Highly Cited
1994
In an attempt to better understand the mechanisms for pseudoalcoholic liver lesions in human beings, we determined the effects of… Expand
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Review
1983
Review
1983
The discovery of Ca++ antagonism as a new principle of action of coronary drugs reaches back to 1964, when we reported that two… Expand
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