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Perhexiline
Known as:
Piperidine, 2-(2,2-dicyclohexylethyl)-
, 2-(2,2-Dicyclohexylethyl)piperidine
, Perhexiline [Chemical/Ingredient]
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2-(2,2-Dicyclohexylethyl)piperidine. Coronary vasodilator used especially for angina of effort. It may cause neuropathy and hepatitis.
National Institutes of Health
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Related topics
Related topics
13 relations
Broader (4)
Calcium Channel Blockers
Cardiovascular Agents
Vasodilator Agents
piperidine
In Blood
agonists
analogs & derivatives
antagonists & inhibitors
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Narrower (2)
hydroxyperhexiline
perhexiline maleate
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2005
Review
2005
Metabolic Therapy for Ischemic Heart Disease: The Rationale for Inhibition of Fatty Acid Oxidation
W. Stanley
,
H. Sabbah
Heart Failure Reviews
2005
Corpus ID: 13566998
Myocardial ischemia is a metabolic disease: oxygen delivery to the myocardium is abnormally low, resulting in reduced formation…
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2002
2002
Association of aortic stenosis with platelet hyperaggregability and impaired responsiveness to nitric oxide.
Y. Chirkov
,
Andrew S. Holmes
,
S. Willoughby
,
S. Stewart
,
J. Horowitz
American Journal of Cardiology
2002
Corpus ID: 27220050
Highly Cited
2002
Highly Cited
2002
Beneficial clinical effects of perhexiline in patients with stable angina pectoris and acute coronary syndromes are associated with potentiation of platelet responsiveness to nitric oxide.
S. Willoughby
,
Simon Stewart
,
Y. Chirkov
,
J. Kennedy
,
Andrew S. Holmes
,
John D. Horowitz
European Heart Journal
2002
Corpus ID: 19814628
AIMS To examine whether the prophylactic antianginal agent perhexiline potentiates platelet responsiveness to nitric oxide (NO…
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Review
1992
Review
1992
Genetically determined differences in drug metabolism as a risk factor in drug toxicity.
M. Eichelbaum
,
H. Kroemer
,
G. Mikus
Toxicology Letters
1992
Corpus ID: 13729376
1986
1986
Modulation of vascular and cardiac contractile protein regulatory mechanisms by calmodulin inhibitors and related compounds.
P. Silver
,
P. B. Pinto
,
J. Dachiw
Biochemical Pharmacology
1986
Corpus ID: 23157406
1986
1986
Stereoselective pharmacokinetics of perhexiline.
B. J. Gould
,
A. Amoah
,
D. Parke
Xenobiotica; the fate of foreign compounds in…
1986
Corpus ID: 25177254
Blood plasma and urine excretion pharmacokinetics of the (+) and (-) enantiomers of perhexiline have been determined in oral…
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1984
1984
The effect of verapamil and other calcium antagonists on chemotaxis of polymorphonuclear leukocytes.
J. Elferink
,
M. Deierkauf
Biochemical Pharmacology
1984
Corpus ID: 25100457
Highly Cited
1982
Highly Cited
1982
Characterization of [3H]nifedipine binding sites in rabbit myocardium.
M. Holck
,
S. Thorens
,
Guenther Haeusler
European Journal of Pharmacology
1982
Corpus ID: 4605632
1981
1981
Effect of Ca2+-antagonistic vasodilators, diltiazem, nifedipine, perhexiline and verapamil, on platelet aggregation in vitro.
H. Ono
,
M. Kimura
Arzneimittel-Forschung
1981
Corpus ID: 41428030
Ca2+-Antagonistic vasodilators, diltiazem, nifedipine, perhexiline and verapamil, showed inhibitory activity on platelet…
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1971
1971
Perhexilene maleate in treatment of angina pectoris.
L. J. Lyon
,
M. Nevins
,
S. Risch
,
S. Henry
The Lancet
1971
Corpus ID: 30732882
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