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Perhexiline

Known as: Piperidine, 2-(2,2-dicyclohexylethyl)-, 2-(2,2-Dicyclohexylethyl)piperidine, Perhexiline [Chemical/Ingredient] 
2-(2,2-Dicyclohexylethyl)piperidine. Coronary vasodilator used especially for angina of effort. It may cause neuropathy and hepatitis.
National Institutes of Health

Related topics

Related topics

13 relations

Broader (4)

Calcium Channel BlockersCardiovascular AgentsVasodilator Agentspiperidine
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Narrower (2)

hydroxyperhexilineperhexiline maleate

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2004
2004
Drug interactions-information, education, and the British National Formulary.
The drug interactions appendix in the current issue of the British National Formulary lists about 3000 interactions or groups of… 
Highly Cited
2002
Highly Cited
2002
Beneficial clinical effects of perhexiline in patients with stable angina pectoris and acute coronary syndromes are associated with potentiation of platelet responsiveness to nitric oxide.
AIMS To examine whether the prophylactic antianginal agent perhexiline potentiates platelet responsiveness to nitric oxide (NO… 
2002
2002
Association of aortic stenosis with platelet hyperaggregability and impaired responsiveness to nitric oxide.
1986
1986
Modulation of vascular and cardiac contractile protein regulatory mechanisms by calmodulin inhibitors and related compounds.
1986
1986
Stereoselective pharmacokinetics of perhexiline.
Blood plasma and urine excretion pharmacokinetics of the (+) and (-) enantiomers of perhexiline have been determined in oral… 
1985
1985
Comparison of negative inotropic potency, reversibility, and effects on calcium influx of six calcium channel antagonists in cultured myocardial cells
1 The negative inotropic effects of calcium channel antagonists on the myocardium were used as a standard for the definition and… 
1984
1984
The effect of verapamil and other calcium antagonists on chemotaxis of polymorphonuclear leukocytes.
1981
1981
Vasodilating Effects of Perhexiline, Glyceryl Trinitrate, and Verapamil on the Coronary, Femoral, Renal, and Mesenteric Vasculature of the Dog
Summary We compared the vasodilator effects of perhexiline on canine coronary, femoral, renal, and mesenteric arteries with those… 
1971
1971
Perhexilene maleate in treatment of angina pectoris.
1970
1970
Pharmacology of a new antianginal drug: perhexiline. I. Coronary circulation and myocardial metabolism.
In the anesthetized dog with right-heart bypass the injection of perhexiline was followed by the vasodilatation of the coronary… 
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