Perhexiline

Known as: Piperidine, 2-(2,2-dicyclohexylethyl)-, 2-(2,2-Dicyclohexylethyl)piperidine, Perhexiline [Chemical/Ingredient] 
2-(2,2-Dicyclohexylethyl)piperidine. Coronary vasodilator used especially for angina of effort. It may cause neuropathy and hepatitis.
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
BACKGROUND Mammalian target of rapamycin complex 1 (mTORC1) is a protein kinase that relays nutrient availability signals to… (More)
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Review
2009
Review
2009
The hypothesis proposed is that heart failure (HF) is associated with a reactive hyperadrenergic state that increases circulating… (More)
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Highly Cited
2005
Highly Cited
2005
BACKGROUND Chronic heart failure (CHF) is a major cause of morbidity and mortality that requires a novel approach to therapy… (More)
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2003
2003
Perhexiline is metabolized by CYP2D6 and has concentration-related hepatoxicity and peripheral neuropathy. The risk of toxicity… (More)
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Highly Cited
1998
Highly Cited
1998
BACKGROUND & AIMS 4,4'-Diethylaminoethoxyhexestrol (DEAEH), amiodarone, and perhexiline cause steatohepatitis in humans. The… (More)
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Highly Cited
1996
Highly Cited
1996
The mechanism of the anti-anginal effect of perhexiline is unclear but appears to involve a shift in cardiac metabolism from… (More)
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Review
1995
Review
1995
Severe and prolonged impairment of mitochondrial beta-oxidation leads to microvesicular steatosis, and, in severe forms, to liver… (More)
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1994
1994
In an attempt to better understand the mechanisms for pseudoalcoholic liver lesions in human beings, we determined the effects of… (More)
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1986
1986
Blood plasma and urine excretion pharmacokinetics of the (+) and (-) enantiomers of perhexiline have been determined in oral… (More)
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Review
1983
Review
1983
The discovery of Ca++ antagonism as a new principle of action of coronary drugs reaches back to 1964, when we reported that two… (More)
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