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Perhexiline

Known as: Piperidine, 2-(2,2-dicyclohexylethyl)-, 2-(2,2-Dicyclohexylethyl)piperidine, Perhexiline [Chemical/Ingredient] 
2-(2,2-Dicyclohexylethyl)piperidine. Coronary vasodilator used especially for angina of effort. It may cause neuropathy and hepatitis.
National Institutes of Health

Related topics

Related topics

13 relations

Broader (4)

Calcium Channel BlockersCardiovascular AgentsVasodilator Agentspiperidine
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Narrower (2)

hydroxyperhexilineperhexiline maleate

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2005
Review
2005
Metabolic Therapy for Ischemic Heart Disease: The Rationale for Inhibition of Fatty Acid Oxidation
Myocardial ischemia is a metabolic disease: oxygen delivery to the myocardium is abnormally low, resulting in reduced formation… 
2002
2002
Association of aortic stenosis with platelet hyperaggregability and impaired responsiveness to nitric oxide.
Highly Cited
2002
Highly Cited
2002
Beneficial clinical effects of perhexiline in patients with stable angina pectoris and acute coronary syndromes are associated with potentiation of platelet responsiveness to nitric oxide.
AIMS To examine whether the prophylactic antianginal agent perhexiline potentiates platelet responsiveness to nitric oxide (NO… 
Review
1992
Review
1992
Genetically determined differences in drug metabolism as a risk factor in drug toxicity.
1986
1986
Modulation of vascular and cardiac contractile protein regulatory mechanisms by calmodulin inhibitors and related compounds.
1986
1986
Stereoselective pharmacokinetics of perhexiline.
Blood plasma and urine excretion pharmacokinetics of the (+) and (-) enantiomers of perhexiline have been determined in oral… 
1984
1984
The effect of verapamil and other calcium antagonists on chemotaxis of polymorphonuclear leukocytes.
Highly Cited
1982
Highly Cited
1982
Characterization of [3H]nifedipine binding sites in rabbit myocardium.
1981
1981
Effect of Ca2+-antagonistic vasodilators, diltiazem, nifedipine, perhexiline and verapamil, on platelet aggregation in vitro.
Ca2+-Antagonistic vasodilators, diltiazem, nifedipine, perhexiline and verapamil, showed inhibitory activity on platelet… 
1971
1971
Perhexilene maleate in treatment of angina pectoris.
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