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Peptichemio

Known as: peptide bound m-L-sarcolysin, Peptichemio [Chemical/Ingredient], Multialchilpeptide 
A mixture of six synthetic oligopeptides in which the peptides are conjugated to metamelphalan, with alkylating and potential antineoplastic activity… 
National Institutes of Health

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Broader (2)

Antimetabolites, AntineoplasticAntineoplastic Agents, Alkylating
In BloodNCIt Antineoplastic Agent Terminologyagonistsanalogs & derivatives

Papers overview

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1991
1991
Increased toxicity and DNA cross-linking by peptide bound m-L-sarcolysin (Peptichemio) as compared to melphalan and m-L-sarcolysin in human melanoma cell lines.
Alteration of the melphalan molecule by shifting the di(2-choroethyl)aminogroup from the para- to the meta-position of the… 
1987
1987
Localized neuroblastoma. Surgical and pathologic staging
Sixty‐five children with neuroblastoma without evidence of distant metastases underwent initial tumor resection. Seventeen with… 
1985
1985
Treatment of multiple myeloma: a randomized study of three different regimens.
1985
1985
Rate of M-component changes and plasma cell labeling index in 25 patients with multiple myeloma treated with peptichemio.
Twenty-five consecutive patients with previously untreated multiple myeloma were studied for bone marrow plasma cell labeling… 
1982
1982
Effect of peptichemio in nonlocalized neuroblastoma
PTC, a mixture of oligopeptides of m‐L‐sarcholysin, acting primarily as an alkylating agent, was utilized as initial therapy… 
1980
1980
A phase II study of peptichemio in advanced breast cancer
A phase II trial of Peptichemio (PTC) was conducted on 56 patients with advanced breast cancer that had been resistant to… 
1979
1979
Clinical evaluation of peptichemio.
Peptichemio is a peptide complex of m-L-phenylalanine mustard. A clinical evaluation of this agent was conducted in 116 patients… 
1978
1978
Peptichemio in advanced neuroblastoma.
Peptichemio (PTC) is a mixture of six synthetic peptides of m-L-phenylalanine mustard. It acts with both alkylating and… 
1978
1978
Clinical trial of peptichemio in solid tumors of childhood.
Peptichemio (PTC) was utilized in various advanced and disseminated tumors in children. With the schedule that was used, toxicity… 
1977
1977
Lethal and kinetic effects of peptichemio on cultured human lymphoma cells.
Summary The lethal and cytokinetic effects of peptichemio (multipeptide complex of m -[di(2-chloroethyl)amino]-l-phenylalanine… 
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