Penicillanic Acid

Class D β-lactamases represent a growing and diverse class of penicillin-inactivating enzymes that are usually resistant to… Expand

Clinical use of beta-lactams has selected for beta-lactamase-producing organisms. Numerous beta-lactamases are known, and… Expand

Three new sulfonylamido-penicillanic acid sulfones have been prepared by reaction of 6-aminopenicillanic esters with the… Expand

When penicillanic acid sulfone in large molar excess is incubated with the RTEM beta-lactamase, the enzyme becomes inactivated… Expand

The interaction of the sulfone of penicillanic acid with the TEM-2 beta-lactamase from Escherichia coli has been investigated as… Expand

The in vitro activity of mecillinam, a 6 β-amidinopenicillanic acid derivative, was investigated. Mecillinam is not active… Expand

Three out of four workers from an antibiotic‐producing factory developed late asthma and eosinophilia on inhalation challenge… Expand

An appraisal is made of toxic, microbiogenic, and allergic side effects occurring in man as a result of large amounts of… Expand

WHILE preparing and investigating the properties of penicillanic acid (IVa) and its derivatives, we have found that it is… Expand

THE nucleus of the penicillin molecule, 6-aminopenicillanic acid (I)1, is in some respects more stable than most penicillins (II… Expand