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Penicillanic Acid

Known as: Acid, Penicillanic, Penicillanic acids, Penicillanic Acid [Chemical/Ingredient] 
A building block of penicillin, devoid of significant antibacterial activity. (From Merck Index, 11th ed)
National Institutes of Health

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30 relations

Narrower (22)

6,6-bis(hydroxylmethyl)penicillanate6-acetylmethylenepenicillanic acid6-chloropenicillanic acid S-sulfoxideAO 1100
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Broader (1)

Anti-Bacterial Agents
In Bloodagonistsanalogs & derivativesantagonists & inhibitors
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Design, synthesis, and crystal structures of 6-alkylidene-2'-substituted penicillanic acid sulfones as potent inhibitors of Acinetobacter baumannii OXA-24 carbapenemase.
Class D β-lactamases represent a growing and diverse class of penicillin-inactivating enzymes that are usually resistant to… 
Review
1998
Review
1998
Beta-lactamase-mediated resistance and opportunities for its control.
  • D. Livermore
  • The Journal of antimicrobial chemotherapy
  • 1998
  • Corpus ID: 17894362
Clinical use of beta-lactams has selected for beta-lactamase-producing organisms. Numerous beta-lactamases are known, and… 
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  • table IV
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  • table V
1984
1984
Penicillanic acid sulfone: nature of irreversible inactivation of RTEM beta-lactamase from Escherichia coli.
When penicillanic acid sulfone in large molar excess is incubated with the RTEM beta-lactamase, the enzyme becomes inactivated… 
1981
1981
Penicillanic acid sulfone: interaction with RTEM beta-lactamase from Escherichia coli at different pH values.
The interaction of the sulfone of penicillanic acid with the TEM-2 beta-lactamase from Escherichia coli has been investigated as… 
Highly Cited
1976
Highly Cited
1976
Mecillinam, a Novel Penicillanic Acid Derivative with Unusual Activity Against Gram-Negative Bacteria
  • H. Neu
  • Antimicrobial Agents and Chemotherapy
  • 1976
  • Corpus ID: 22221510
The in vitro activity of mecillinam, a 6 β-amidinopenicillanic acid derivative, was investigated. Mecillinam is not active… 
Highly Cited
1974
Highly Cited
1974
Asthma due to inhaled chemical agents: ampicillin, benzyl penicillin, 6 amino penicillanic acid and related substances
Three out of four workers from an antibiotic‐producing factory developed late asthma and eosinophilia on inhalation challenge… 
Highly Cited
1968
Highly Cited
1968
Nature and extent of penicillin side-reactions, with particular reference to fatalities from anaphylactic shock.
An appraisal is made of toxic, microbiogenic, and allergic side effects occurring in man as a result of large amounts of… 
Highly Cited
1965
Highly Cited
1965
Resistance of Escherichia coli to Penicillins I. Genetic Study of Some Ampicillin-Resistant Mutants
Eriksson-Grennberg, Kerstin G. (University of Uppsala, Uppsala, Sweden), Hans G. Boman, J. A. Torbjörn Jansson, and Sone Thorén… 
1964
1964
Gas Chromatography of Penicillin and Penicillanic Acid Esters
WHILE preparing and investigating the properties of penicillanic acid (IVa) and its derivatives, we have found that it is… 
1961
1961
Action of Carbon Dioxide on 6-Amino-penicillanic Acid
THE nucleus of the penicillin molecule, 6-aminopenicillanic acid (I)1, is in some respects more stable than most penicillins (II… 
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