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Patient Derived Xenograft

Known as: Patient-Derived Xenograft, PDX, Patient-Derived Xenograft Model 
The transfer of a tumor fragment from a patient into an immunodeficient mouse.
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Synergistic Activity of IDH1 Inhibitor Bay-1436032 with Azacitidine in IDH1 Mutant Acute Myeloid Leukemia
Background: Only about one third of AML patients with mutant IDH1 respond to IDH1 inhibitor monotherapy with a median response… 
2017
2017
Patient-Derived Xenografts in Oncology
Cancer is among the leading causes of death worldwide. In 2012, approximately 14 million new cases and about eight million cancer… 
Review
2016
Review
2016
Patient-derived tumor xenograft models for melanoma drug discovery
ABSTRACT Introduction: Cutaneous metastatic melanoma (MM) is an aggressive form of skin cancer, with treatment providing cures to… 
Review
2015
Review
2015
From autonomy to community; new perspectives on tumorigenicity and therapy resistance.
2014
2014
Targeted Hsp70 expression combined with CIK-activated immune reconstruction synergistically exerts antitumor efficacy in patient-derived hepatocellular carcinoma xenograft mouse models
The patient-derived tumor xenograft (PDTX) models can reproduce a similar natural genetic background and similar biological… 
2014
2014
Patient Derived Xenograft (PDX) Models Recapitulate the Genomic-Driver Composition of Acute Leukemia Samples
Xenotransplantation of primary AML samples into immunodeficient mice (PDX models) represents a unique opportunity for pre… 
2013
2013
A patient-derived xenograft mouse model generated from primary cultured cells recapitulates patient tumors phenotypically and genetically
BackgroundPreclinical trials of cancer therapeutics require both in vitro and in vivo evaluations. Recently, a patient-derived… 
2013
2013
Patient-derived tumor xenograft model to guide the use of BRAF inhibitors in metastatic melanoma
Recently, the BRAF V600 inhibitor, vemurafenib, has revolutionized the therapeutic management of metastatic melanoma. However… 
2011
2011
Abstract 4504: PF-04449913, a small molecule inhibitor of Hedgehog signaling, is effective in inhibiting tumor growth in preclinical models
Aberrant activation of the Hedgehog (Hh) signaling pathway has been implicated in several human cancers. Mutations in the Patched… 
1988
1988
Helium, tritium, and protium NMR studies of tritide-free aged PdTx.
Pulsed NMR relaxation-time measurements have been performed on PdT/sub x/, aged approximately eight years, after first removing… 
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