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Comprehensive genomic profiles of small cell lung cancer
We have sequenced the genomes of 110 small cell lung cancers (SCLC), one of the deadliest human cancers. In nearly all the tumours analysed we found bi-allelic inactivation of TP53 and RB1, sometimes… Expand
Prognosis of fibrotic interstitial pneumonia: idiopathic versus collagen vascular disease-related subtypes.
- J. Park, D. Kim, +4 authors T. Colby
- American journal of respiratory and critical care…
- 1 April 2007
BACKGROUND To investigate whether the better prognosis of interstitial pneumonias associated with collagen vascular disease (CVD) compared with idiopathic interstitial pneumonia (IIP) is due to… Expand
Clinicopathologic review of 58 patients with biliary papillomatosis
Biliary papillomatosis (BP) is a rare disease that is characterized by multiple numerous papillary adenomas in the biliary tree. The clinical features and outcome, however, are not well known. The… Expand
Genomic portrait of resectable hepatocellular carcinomas: Implications of RB1 and FGF19 aberrations for patient stratification
Hepatic resection is the most curative treatment option for early‐stage hepatocellular carcinoma, but is associated with a high recurrence rate, which exceeds 50% at 5 years after surgery.… Expand
Pathologic and radiologic differences between idiopathic and collagen vascular disease-related usual interstitial pneumonia.
BACKGROUND Patients with usual interstitial pneumonia (UIP) associated with collagen vascular disease (CVD) have been reported to have a better prognosis than those with idiopathic pulmonary fibrosis… Expand
Acute exacerbation of interstitial pneumonia other than idiopathic pulmonary fibrosis.
BACKGROUND Acute exacerbation (AE) in idiopathic pulmonary fibrosis (IPF) is increasingly recognized as a relatively common and highly morbid clinical event. However, clinical data on AE in non-IPF… Expand
Expression of Aquaporin 5 (AQP5) Promotes Tumor Invasion in Human Non Small Cell Lung Cancer
The aquaporins (AQP) are water channel proteins playing a major role in transcellular and transepithelial water movement. Recently, the role of AQPs in human carcinogenesis has become an area of… Expand
Blood biomarkers MMP-7 and SP-A: predictors of outcome in idiopathic pulmonary fibrosis.
BACKGROUND Because of the variable course of idiopathic pulmonary fibrosis (IPF), it is important to generate an accurate prognosis at the time of diagnosis. The aim of this study was to investigate… Expand
Patient-derived lung cancer organoids as in vitro cancer models for therapeutic screening
Lung cancer shows substantial genetic and phenotypic heterogeneity across individuals, driving a need for personalised medicine. Here, we report lung cancer organoids and normal bronchial organoids… Expand
The Global Histone Modification Pattern Correlates with Cancer Recurrence and Overall Survival in Gastric Adenocarcinoma
- Y. Park, M. Jin, Y. Kim, J. Yook, B. S. Kim, S. Jang
- Biology, Medicine
- Annals of Surgical Oncology
- 10 May 2008
BackgroundEpigenetic alterations such as DNA methylation and histone modification play important roles in carcinogenesis. It has been recently suggested that global histone modification patterns are… Expand