Pactamycin

Known as: Benzoic acid, 2-hydroxy-6-methyl-, (5-((3-acetylphenyl)amino)-4-amino-3-(((dimethylamino)carbonyl)amino)-1,2-dihydroxy-3-(1-hydroxyethyl)-2-methylcyclopentyl)methyl ester, (1S-(1alpha,2beta,3alpha,3(R*),4alpha,5beta))-, Pactamycin [Chemical/Ingredient] 
Antibiotic produced by Streptomyces pactum used as an antineoplastic agent. It is also used as a tool in biochemistry because it inhibits certain… (More)

Topic mentions per year

Topic mentions per year

1962-2017
05101519622017

Papers overview

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2009
2009
Pactamycin is an aminocyclopentitol-derived natural product that has potent antibacterial and antitumor activities. Sequence… (More)
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2004
2004
The crystal structures of the universal translation-initiation inhibitors edeine and pactamycin bound to ribosomal 30S subunit… (More)
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Highly Cited
2000
Highly Cited
2000
We have used the recently determined atomic structure of the 30S ribosomal subunit to determine the structures of its complexes… (More)
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Highly Cited
1998
Highly Cited
1998
We have identified gas5 (growth arrest-specific transcript 5) as a non-protein-coding multiple small nucleolar RNA (snoRNA) host… (More)
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Highly Cited
1995
Highly Cited
1995
Gene rearrangement during the ontogeny of T- and B-cells generates an enormous repertoire of T-cell receptor (TCR) and… (More)
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1990
1990
A pactamycin (Pc)-resistance determinant (pct) from Streptomyces pactum has been isolated on a 4.9-kb KpnI fragment. The original… (More)
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1985
1985
Pactamycin, an inhibitor of the initial steps of protein synthesis, has an acetophenone group in its chemical structure that… (More)
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1976
1976
Earlier work has shown that the inhibition by pactamycin (PM) of polypeptide chain initiation in reticulocyte extracts is… (More)
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1973
1973
Pactamycin does not inhibit the overall initiation factor- and GTP-dependent binding of [(35)S]Met-tRNA(f) to rabbit reticulocyte… (More)
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1962
1962
The optimal fermentation conditions for the production of pactamycin, a new antitumor antibiotic, by Streptomyces pactum var… (More)
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