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Pactamycin

Known as: Benzoic acid, 2-hydroxy-6-methyl-, (5-((3-acetylphenyl)amino)-4-amino-3-(((dimethylamino)carbonyl)amino)-1,2-dihydroxy-3-(1-hydroxyethyl)-2-methylcyclopentyl)methyl ester, (1S-(1alpha,2beta,3alpha,3(R*),4alpha,5beta))-, Pactamycin [Chemical/Ingredient] 
Antibiotic produced by Streptomyces pactum used as an antineoplastic agent. It is also used as a tool in biochemistry because it inhibits certain… 
National Institutes of Health

Related topics

Related topics

13 relations

Broader (2)

Antibiotics, AntineoplasticProtein Synthesis Inhibitors
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Narrower (4)

TM-025TM-026cranomycinjogyamycin

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Interrogating the Tailoring Steps of Pactamycin Biosynthesis and Accessing New Pactamycin Analogues
Pactamycin is a bacteria‐derived aminocyclitol antibiotic with a wide‐range of biological activity. Its chemical structure and… 
2012
2012
Access to the pactamycin core via an epoxide opening cascade.
A synthetic strategy to establish five contiguous stereocenters, in a stereocontrolled manner, on the core structure of… 
2012
2012
Diastereocontrolled construction of pactamycin's complex ureido triol functional array.
An advanced intermediate in a projected synthesis of pactamycin has been prepared. Early installation of the C1-dimethylurea… 
1985
1985
Photoaffinity labeling of the pactamycin binding site on eubacterial ribosomes.
Pactamycin, an inhibitor of the initial steps of protein synthesis, has an acetophenone group in its chemical structure that… 
1978
1978
Carbon-13 nuclear magnetic resonance assignments of pactamycin and related compounds.
All resonances observed in the 13C NMR spectrum of the antitumor antibiotic pactamycin and its degradation product pactamyçate… 
1978
1978
Proteins of Rous-associated virus 61, an avian retrovirus: common precursor for glycoproteins gp85 and gp35 and use of pactamycin to map translational order of proteins in the gag, pol, and env genes
Cells infected by Rous-associated virus 61 (RAV-61) contained a precursor-like protein, pr90, that was specifically precipitated… 
Highly Cited
1977
Highly Cited
1977
Common Precursor for Rauscher Leukemia Virus gp69/71, p15(E), and p12(E)
Rauscher murine leukemia virus glycoprotein gp69/71 and non-glycosylated p15(E) are synthesized by way of a 90,000-dalton… 
Highly Cited
1977
Highly Cited
1977
Mutants of CHO cells resistant to the protein synthesis inhibitors, cryptopleurine and tylocrebrine: genetic and biochemical evidence for common site of action of emetine, cryptopleurine, tylocrebine…
Stable mutants resistant to the protein synthesis inhibitors cryptopleurine and tylocrebine can be isolated in Chinese hamster… 
1976
1976
Secretion of Ia antigens by a subpopulation of T cells which are Ly-1+, Ly-2-, and Ia-
It was found that Ia antignes are rapidly secreted by a subpopulation of splenic T lymphocytes which are nonadherent and which… 
Highly Cited
1972
Highly Cited
1972
Specific inhibition of peptide-chain initiation by 2-(4-methyl-2,6-dinitroanilino)-N-methylpropionamide.
M DMP (2-(4-methyl-2,6-dinitroanilino)-N-methyl- propionamide) is a potent inhibitor of mRNA-dependent amino acid incorporation… 
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