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Pactamycin

Known as: Benzoic acid, 2-hydroxy-6-methyl-, (5-((3-acetylphenyl)amino)-4-amino-3-(((dimethylamino)carbonyl)amino)-1,2-dihydroxy-3-(1-hydroxyethyl)-2-methylcyclopentyl)methyl ester, (1S-(1alpha,2beta,3alpha,3(R*),4alpha,5beta))-, Pactamycin [Chemical/Ingredient] 
Antibiotic produced by Streptomyces pactum used as an antineoplastic agent. It is also used as a tool in biochemistry because it inhibits certain… 
National Institutes of Health

Related topics

Related topics

13 relations

Broader (2)

Antibiotics, AntineoplasticProtein Synthesis Inhibitors
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Narrower (4)

TM-025TM-026cranomycinjogyamycin

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2011
Highly Cited
2011
Total synthesis of pactamycin.
The compound is synthesized in 29 linear steps and 3% overall yield starting from a known oxazoline readily available from L… 
Highly Cited
1998
Highly Cited
1998
Estradiol regulates estrogen receptor mRNA stability
Highly Cited
1982
Highly Cited
1982
Identification of the carboxyl peptides of mouse procollagen IV and its implications for the assembly and structure of basement membrane procollagen.
Highly Cited
1978
Highly Cited
1978
The induction of ovalbumin and conalbumin mRNA by estrogen and progesterone in chick oviduct explant cultures
Highly Cited
1976
Highly Cited
1976
Role of changes in protein degradation in the growth of regenerating livers.
Highly Cited
1974
Highly Cited
1974
Release of the inhibition of messenger RNA translation in extracts of interferon-treated Ehrlich ascites tumor cells by added transfer RNA.
Highly Cited
1972
Highly Cited
1972
Evidence for an accumulation of messenger RNA specific for extracellular protease and its relevance to the mechanism of enzyme secretion in bacteria.
Highly Cited
1971
Highly Cited
1971
Inhibitors of protein synthesis by ribosomes of the 80-S type.
Highly Cited
1971
Highly Cited
1971
Effect of Pactamycin on Synthesis of Poliovirus Proteins: a Method for Genetic Mapping
We have studied the effect of the drug pactamycin on protein synthesis in poliovirus-infected HeLa cells. At a concentration… 
Highly Cited
1966
Highly Cited
1966
Inhibition of protein synthesis in reticulocytes by antibiotics. I. Effects on polysomes.
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