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Pactamycin

Known as: Benzoic acid, 2-hydroxy-6-methyl-, (5-((3-acetylphenyl)amino)-4-amino-3-(((dimethylamino)carbonyl)amino)-1,2-dihydroxy-3-(1-hydroxyethyl)-2-methylcyclopentyl)methyl ester, (1S-(1alpha,2beta,3alpha,3(R*),4alpha,5beta))-, Pactamycin [Chemical/Ingredient] 
Antibiotic produced by Streptomyces pactum used as an antineoplastic agent. It is also used as a tool in biochemistry because it inhibits certain… Expand
National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
Malaria inflicts an enormous burden on global human health. The emergence of parasite resistance to front-line drugs has prompted… Expand
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2013
2013
Preparing Pactamycin Microbially derived organic compounds often have remarkably intricate structures that confer striking… Expand
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2012
2012
This article describes synthetic studies that culminated in the first total synthesis of pactamycin and pactamycate and, in… Expand
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Highly Cited
2009
Highly Cited
2009
Pactamycin is an aminocyclopentitol-derived natural product that has potent antibacterial and antitumor activities. Sequence… Expand
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Highly Cited
2004
Highly Cited
2004
The crystal structures of the universal translation-initiation inhibitors edeine and pactamycin bound to ribosomal 30S subunit… Expand
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Highly Cited
2000
Highly Cited
2000
We have used the recently determined atomic structure of the 30S ribosomal subunit to determine the structures of its complexes… Expand
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Highly Cited
1998
Highly Cited
1998
ABSTRACT We have identified gas5 (growth arrest-specific transcript 5) as a non-protein-coding multiple small nucleolar RNA… Expand
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Review
1997
Review
1997
Mutants of an archaeon Halobacterium halobium, resistant to the universal inhibitor of translation, pactamycin, were isolated… Expand
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Highly Cited
1995
Highly Cited
1995
Gene rearrangement during the ontogeny of T- and B-cells generates an enormous repertoire of T-cell receptor (TCR) and… Expand
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Highly Cited
1987
Highly Cited
1987
We have previously identified by cDNA cloning 5 mRNAs that appear in resting BALB/c 3T3 cells soon after growth stimulation by… Expand
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