Paclitaxel

Known as: (2AR-(2aalpha,4beta,4abeta,6beta,9alpha(alpha r*,betas*),11alpha,12alpha,12balpha))-beta-(benzoylamino)-alpha-hydroxybenzenepropanoic acid 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester, Benzenepropanoic acid, beta-(benzoylamino)-alpha-hydroxy-, 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester, (2aR-(2aalph, 5beta,20-Epoxy-1,2-alpha,4,7beta,10beta,13alpha-hexahydroxytax-11-en-9-one 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine 
A compound extracted from the Pacific yew tree Taxus brevifolia with antineoplastic activity. Paclitaxel binds to tubulin and inhibits the… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1937-2018
01000200019372017

Papers overview

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Review
2017
Review
2017
In recent years, the nanotechnology has offered researchers the opportunity to solve the problems caused by the vehicle of the… (More)
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Review
2017
Review
2017
Efficient intracellular trafficking and targeted delivery to the site of action are essential to overcome the current drawbacks… (More)
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Review
2016
Review
2016
OBJECTIVE To estimate per-event cost and economic burden associated with managing the most common and/or severe metastatic… (More)
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Highly Cited
2009
Highly Cited
2009
BACKGROUND Previous, uncontrolled studies have suggested that first-line treatment with gefitinib would be efficacious in… (More)
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Highly Cited
2007
Highly Cited
2007
BACKGROUND In an open-label, randomized, phase 3 trial, we compared the efficacy and safety of paclitaxel with that of paclitaxel… (More)
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Highly Cited
2007
Highly Cited
2007
BACKGROUND The safety of drug-eluting stents has been called into question by recent reports of increased stent thrombosis… (More)
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Highly Cited
2006
Highly Cited
2006
BACKGROUND Bevacizumab, a monoclonal antibody against vascular endothelial growth factor, has been shown to benefit patients with… (More)
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Highly Cited
2006
Highly Cited
2006
BACKGROUND Standard chemotherapy for newly diagnosed ovarian cancer is a platinum-taxane combination. The Gynecologic Oncology… (More)
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Highly Cited
2005
Highly Cited
2005
PURPOSE ABI-007, the first biologically interactive albumin-bound paclitaxel in a nanameter particle, free of solvents, was… (More)
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Highly Cited
2004
Highly Cited
2004
BACKGROUND Restenosis after coronary stenting necessitates repeated percutaneous or surgical revascularization procedures. The… (More)
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