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Paclitaxel

Known as: (2AR-(2aalpha,4beta,4abeta,6beta,9alpha(alpha r*,betas*),11alpha,12alpha,12balpha))-beta-(benzoylamino)-alpha-hydroxybenzenepropanoic acid 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester, Benzenepropanoic acid, beta-(benzoylamino)-alpha-hydroxy-, 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester, (2aR-(2aalph, 5beta,20-Epoxy-1,2-alpha,4,7beta,10beta,13alpha-hexahydroxytax-11-en-9-one 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine 
A compound extracted from the Pacific yew tree Taxus brevifolia with antineoplastic activity. Paclitaxel binds to tubulin and inhibits the… 
National Institutes of Health

Papers overview

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Review
2006
Review
2006
Despite the benefits of the production and use of biofuels in the fields of agriculture, security of energy supply and the… 
2006
2006
”Green Gas” as SNG (Synthetic Natural Gas) can play an important role in the transition process from the present Dutch fossil… 
2000
2000
AIM:To investigate the effects of taxol on SMMC-7721 human hepatoma and its mechanisms.METHODS:In vitro cell growth was assessed… 
Review
1991
Review
1991
Taxol was isolated in 1971 from the stem bark of the plant Taxus brevifolia, (western yew), a small evergreen native to the… 
1989
1989
Two multimodal two dimensional TLC procedures are described for the separation of taxol and cephalomannine from other natural… 
1987
1987
The effects of microtubule inhibitors on cellular accumulation of 4'-demethylepipodophyllotoxin-9-(4,6-O-ethylidine-beta-D-glu… 
Highly Cited
1985
Highly Cited
1985
The distribution of three high molecular weight proteins, MAP-1 (Mr 330 000), MAP-2 (Mr 300 000) and plectin (Mr 300 000) in… 
1985
1985
In Chinese hamster ovary cells, stable mutants exhibiting specific resistance or collateral sensitivity towards the various… 
1984
1984
The involvement of high molecular weight microtubule-associated proteins (HMW-MAPs) in the process of taxol-induced microtubule… 
1984
1984
The fate of the circumferential bundle of microtubules in activated platelets has been a subject of disagreement. Thin sections…