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Paclitaxel

Known as: (2AR-(2aalpha,4beta,4abeta,6beta,9alpha(alpha r*,betas*),11alpha,12alpha,12balpha))-beta-(benzoylamino)-alpha-hydroxybenzenepropanoic acid 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester, Benzenepropanoic acid, beta-(benzoylamino)-alpha-hydroxy-, 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester, (2aR-(2aalph, 5beta,20-Epoxy-1,2-alpha,4,7beta,10beta,13alpha-hexahydroxytax-11-en-9-one 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine 
A compound extracted from the Pacific yew tree Taxus brevifolia with antineoplastic activity. Paclitaxel binds to tubulin and inhibits the… 
National Institutes of Health

Papers overview

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Highly Cited
2003
Highly Cited
1999
Highly Cited
1999
The expression of c-myc promotes cell proliferation and also sensitizes cells to various extracellular apoptotic stimuli. However… 
Highly Cited
1989
Highly Cited
1989
We investigated the effects of calcium removal and calcium ionophores on the behavior and ultrastructure of cultured chick dorsal… 
Highly Cited
1987
Highly Cited
1987
The synchronized directed transfer of the envelope glycoproteins of the influenza and vesicular stomatitis viruses from the Golgi… 
Highly Cited
1984
Highly Cited
1984
Treatment of epithelial African green monkey kidney (BSC-1) cells with the potent tumor promoter 12-O-tetradecanoylphorbol-13… 
Highly Cited
1983
Highly Cited
1983
PC12 rat pheochromocytoma cells respond to nerve growth factor (NGF) protein by shifting from a chromaffin-cell-like phenotype to… 
Highly Cited
1981
Highly Cited
1981
Taxol has the following effects on myogenic cultures: (a) it blocks cell replication of presumptive myoblasts and fibroblasts. (b… 
Highly Cited
1979
Highly Cited
1979
SUMMARY The short-terra cardiovascular and endocrine effects of an orally active anglotensin converting enzyme inhibitor, SQ14…