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Dentin Sialophosphoprotein Knockout Mouse Teeth Display Widened Predentin Zone and Develop Defective Dentin Mineralization Similar to Human Dentinogenesis Imperfecta Type III*
TLDR
The generation of Dspp-null mice that develop tooth defects similar to human dentinogenesis imperfecta III with enlarged pulp chambers, increased width of predentin zone, hypomineralization, and pulp exposure are reported.
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High mobility group A2 is a target for miRNA-98 in head and neck squamous cell carcinoma
TLDR
It is reported that HMGA2 expression in head and neck squamous cell carcinoma (HNSCC) cells is regulated in part by miRNA-98 (miR-98), and the demonstration that miRNA profiles are altered during hypoxia and repress a genotoxic response indicates that changes in microenvironment in eukaryotes mimic those of lower species and plants.
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Mammalian target of rapamycin, a molecular target in squamous cell carcinomas of the head and neck.
TLDR
The Akt-mTOR pathway is identified as a potential therapeutic target for HNSCC, and may provide the rationale for the early clinical evaluation of rapamycin and its analogues in patients with HNS CC.
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Persistent Activation of the Akt Pathway in Head and Neck Squamous Cell Carcinoma
TLDR
Evidence is provided that the Akt signaling pathway may represent a biologically relevant target for a novel antineoplastic agent, UCN-01, which recently has been shown to be active in cellular and xenograft models for HNSCC at concentrations safely achievable in clinically relevant situations.
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Ectopic lingual thyroid
  • J. Sauk
  • Medicine
    The Journal of pathology
  • 1 December 1970
View on Wiley
Human periodontal cells initiate mineral-like nodules in vitro.
TLDR
Differences in behavior between PDL cells and gingival fibroblasts may prove important in designing appropriate clinical therapies directed at stimulating periodontal regeneration.
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Histomorphometric characteristics and expression of epidermal growth factor and its receptor by epithelial cells of normal gingiva and hereditary gingival fibromatosis.
TLDR
The data suggest that EGF and EGFr in the oral epithelium of HGF gingiva may stimulate epithelial cell proliferation, with the resultant apical migration of the oral ephelium and formation of the slender deep epithelial papillae; however, without hyperplastic alterations.
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An amelogenin gene defect associated with human X-linked amelogenesis imperfecta.
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Cyclosporin A induces proliferation in human gingival fibroblasts via induction of transforming growth factor-beta1.
TLDR
The results presented here suggest that CsA stimulatory induction of NG fibroblast proliferation is mediated via TGF-beta1 in an autocrine fashion.
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Oral inflammatory myofibroblastic tumor demonstrating ALK, p53, MDM2, CDK4, pRb, and Ki-67 immunoreactivity in an elderly patient.
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