Skip to search formSkip to main contentSkip to account menu

PXN gene

Known as: PAXILLIN, PXN, Paxillin Gene 
This gene plays a role in cytoskeleton remodeling.
National Institutes of Health

Related topics

Related topics

7 relations
Cell Surface ExtensionsCell-Cell Adhesion ProcessCell-Matrix JunctionCytoskeletal Modeling

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2006
Highly Cited
2006
Focal Adhesions in (Myo)fibroblasts Scaffold Adenylyl Cyclase with Phosphorylated Caveolin*
Fibroblast-myofibroblast transformation, a critical event for enhanced extracellular matrix deposition, involves formation of an… 
Highly Cited
2001
Highly Cited
2001
Depletion of focal adhesion kinase by antisense depresses contractile activation of smooth muscle.
  • D. TangS. Gunst
  • American Journal of Physiology - Cell Physiology
  • 2001
  • Corpus ID: 24836576
Focal adhesion kinase (FAK) undergoes tyrosine phosphorylation in response to the contractile stimulation of tracheal smooth… 
Highly Cited
2000
Highly Cited
2000
Paxillin alpha and Crk-associated substrate exert opposing effects on cell migration and contact inhibition of growth through tyrosine phosphorylation.
Protein tyrosine phosphorylation accompanies and is essential for integrin signaling. We have shown that tyrosine phosphorylation… 
Highly Cited
1999
Highly Cited
1999
Impaired integrin-mediated signal transduction, altered cytoskeletal structure and reduced motility in Hck/Fgr deficient macrophages.
Integrin-mediated adhesion of monocytes and macrophages initiates a signal transduction pathway that leads to actin cytoskeletal… 
Highly Cited
1999
Highly Cited
1999
Dephosphorylation of Focal Adhesion Kinase (FAK) and Loss of Focal Contacts Precede Caspase-mediated Cleavage of FAK during Apoptosis in Renal Epithelial Cells*
The relationship between focal adhesion protein (FAK) activity and loss of cell-matrix contact during apoptosis is not entirely… 
Highly Cited
1999
Highly Cited
1999
Divergent Signaling Pathways Link Focal Adhesion Kinase to Mitogen-activated Protein Kinase Cascades
Stimulation of a number of cell surface receptors, including integrins and G protein-coupled receptors, results in the activation… 
Highly Cited
1998
Highly Cited
1998
Growth Hormone Stimulates the Tyrosine Phosphorylation and Association of p125 Focal Adhesion Kinase (FAK) with JAK2
We have demonstrated that growth hormone (GH) activates focal adhesion kinase (FAK), and this activation results in the tyrosine… 
Highly Cited
1998
Highly Cited
1998
Paxillin Phosphorylation and Association with Lck and Pyk2 in Anti-CD3- or Anti-CD45-stimulated T Cells*
Antibodies to either CD3 or CD45 have been shown to induce dramatic changes in cell morphology, increased tyrosine… 
Highly Cited
1998
Highly Cited
1998
Activation of protein tyrosine kinase PYK2 by the m1 muscarinic acetylcholine receptor.
Several G protein-coupled receptors are known to direct the tyrosine phosphorylation, and in some cases the activation, of… 
Highly Cited
1996
Highly Cited
1996
The Related Adhesion Focal Tyrosine Kinase Forms a Complex with Paxillin in Hematopoietic Cells*
Related adhesion focal tyrosine kinase (RAFTK), also known as proline-rich tyrosine kinase 2 and cellular adhesion kinase β, has… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)