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PXN gene

Known as: PAXILLIN, PXN, Paxillin Gene 
This gene plays a role in cytoskeleton remodeling.
National Institutes of Health

Related topics

Related topics

7 relations
Cell Surface ExtensionsCell-Cell Adhesion ProcessCell-Matrix JunctionCytoskeletal Modeling

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
Paxillin-dependent stimulation of microtubule catastrophes at focal adhesion sites
An organized microtubule array is essential for the polarized motility of fibroblasts. Dynamic microtubules closely interact with… 
Highly Cited
2006
Highly Cited
2006
Evi1 is a survival factor which conveys resistance to both TGFβ- and taxol-mediated cell death via PI3K/AKT
In hematopoietic cells the transforming potential of the ecotropic viral integration site 1 (Evi1) oncogene is thought to be… 
Highly Cited
2003
Highly Cited
2003
Calpain Mediates Progressive Plasma Membrane Permeability and Proteolysis of Cytoskeleton-Associated Paxillin, Talin, and Vinculin during Renal Cell Death
The goal of the present study was to determine the role of calpain in changes in plasma membrane permeability and cytoskeleton… 
Highly Cited
1999
Highly Cited
1999
Impaired integrin-mediated signal transduction, altered cytoskeletal structure and reduced motility in Hck/Fgr deficient macrophages.
Integrin-mediated adhesion of monocytes and macrophages initiates a signal transduction pathway that leads to actin cytoskeletal… 
Highly Cited
1999
Highly Cited
1999
Mechanosensitive tyrosine phosphorylation of paxillin and focal adhesion kinase in tracheal smooth muscle.
We investigated the role of the integrin-associated proteins focal adhesion kinase (FAK) and paxillin as mediators of… 
Highly Cited
1999
Highly Cited
1999
Dephosphorylation of Focal Adhesion Kinase (FAK) and Loss of Focal Contacts Precede Caspase-mediated Cleavage of FAK during Apoptosis in Renal Epithelial Cells*
The relationship between focal adhesion protein (FAK) activity and loss of cell-matrix contact during apoptosis is not entirely… 
Highly Cited
1998
Highly Cited
1998
Serine and threonine phosphorylation of the paxillin LIM domains regulates paxillin focal adhesion localization and cell adhesion to fibronectin.
We have previously shown that the LIM domains of paxillin operate as the focal adhesion (FA)-targeting motif of this protein. In… 
Highly Cited
1997
Highly Cited
1997
Adhesion of fibroblasts to fibronectin stimulates both serine and tyrosine phosphorylation of paxillin.
Tyrosine phosphorylation of paxillin by the focal adhesion kinase (FAK) has been implicated as a signal transduction mechanism… 
Highly Cited
1996
Highly Cited
1996
The Related Adhesion Focal Tyrosine Kinase Forms a Complex with Paxillin in Hematopoietic Cells*
Related adhesion focal tyrosine kinase (RAFTK), also known as proline-rich tyrosine kinase 2 and cellular adhesion kinase β, has… 
Highly Cited
1995
Highly Cited
1995
Focal adhesion formation by F9 embryonal carcinoma cells after vinculin gene disruption.
The assembly of focal adhesions was investigated in F9 embryonal carcinoma cells in which the expression of vinculin was… 
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