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The catalog of human cytokeratins: Patterns of expression in normal epithelia, tumors and cultured cells
Force and focal adhesion assembly: a close relationship studied using elastic micropatterned substrates
The results put clear constraints on the possible molecular mechanisms for the mechanosensory response of focal adhesions to applied force.
Environmental sensing through focal adhesions
- B. Geiger, J. Spatz, A. Bershadsky
- Materials Science, BiologyNature Reviews Molecular Cell Biology
The mechanisms of such environmental sensing are discussed, based on the finely tuned crosstalk between the assembly of one type of integrin-based adhesion complex, namely focal adhesions, and the forces that are at work in the associated cytoskeletal network owing to actin polymerization and actomyosin contraction.
Focal Contacts as Mechanosensors Externally Applied Local Mechanical Force Induces Growth of Focal Contacts by an Mdia1-Dependent and Rock-Independent Mechanism
Experiments show that integrin-containing focal complexes behave as individual mechanosensors exhibiting directional assembly in response to local force, and that external tension force bypasses the requirement for ROCK-mediated myosin II contractility in the induction of focal contacts.
c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor.
An endosomal sorting machinery capable of controlling the fate, and, hence, signaling potency, of growth factor receptors is revealed.
Molecular complexity and dynamics of cell-matrix adhesions.
Integrin-mediated adhesions can undergo dynamic changes in structure and molecular properties from dot-like focal complexes to stress-fiber-associated focal contacts, which can further 'mature' to form fibronectin-bound fibrillar adhesion.
Functional atlas of the integrin adhesome
- R. Zaidel-Bar, S. Itzkovitz, Avi Ma’ayan, R. Iyengar, B. Geiger
- BiologyNature Cell Biology
- 1 August 2007
Examination of the adhesome network motifs reveals a relatively small number of key motifs, dominated by three-component complexes in which a scaffolding molecule recruits both a signalling molecule and its downstream target.
Transmembrane crosstalk between the extracellular matrix--cytoskeleton crosstalk.
This review describes integrin functions, mechanosensors, molecular switches and signal-transduction pathways activated and integrated by adhesion, with a unifying theme being the importance of local physical forces.
Vinculin controls focal adhesion formation by direct interactions with talin and actin
- J. Humphries, Pengbo Wang, C. Streuli, B. Geiger, M. Humphries, C. Ballestrem
- BiologyThe Journal of cell biology
- 3 December 2007
The vinculin head regulates integrin dynamics and clustering and the tail regulates the link to the mechanotransduction force machinery, which is responsible for the functional link of FAs to the actin cytoskeleton.
Early molecular events in the assembly of matrix adhesions at the leading edge of migrating cells
Interestingly, double color, time-lapse movies visualizing both paxillin and zyxin, indicated that the transition frompaxillin-rich focal complexes to definitive,Zyxin-containing focal adhesions, takes place only after the leading edge stops advancing or retracts, illuminating, for the first time, early stages in focal complex assembly and the dynamic process associated with its transformation into focal adhesion.