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PTPRK protein, human

Known as: Protein Tyrosine Phosphatase Kappa, Protein Tyrosine Phosphatase, Receptor Type, K, PTPRK 
Receptor-type tyrosine-protein phosphatase kappa (1439 aa, ~162 kDa) is encoded by the human PTPRK gene. This protein is involved in protein… 
National Institutes of Health

Related topics

Related topics

19 relations
Cell Migration Inhibition functionCell-Cell Adhesion ProcessDephosphorylationEnzyme Gene

Broader (2)

Protein Tyrosine Phosphatase, Receptor Type KReceptor-Like Protein Tyrosine Phosphatases, Class 2

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
The homophilic receptor PTPRK selectively dephosphorylates multiple junctional regulators to promote cell–cell adhesion
Cell-cell communication in multicellular organisms depends on the dynamic and reversible phosphorylation of protein tyrosine… 
Highly Cited
2015
Highly Cited
2015
Receptor-type tyrosine-protein phosphatase κ directly targets STAT3 activation for tumor suppression in nasal NK/T-cell lymphoma.
Nasal-type natural killer/T-cell lymphoma (NKTCL) is an aggressive disease characterized by frequent deletions on 6q, and… 
2010
2010
Comparative quantitation of aberrant glycoforms by lectin-based glycoprotein enrichment coupled with multiple-reaction monitoring mass spectrometry.
Lectin enrichment-coupled multiple-reaction monitoring (MRM) mass spectrometry was employed to quantitatively monitor the… 
Highly Cited
2008
Highly Cited
2008
Down-regulation of the TGF-beta target gene, PTPRK, by the Epstein-Barr virus encoded EBNA1 contributes to the growth and survival of Hodgkin lymphoma cells.
The Epstein-Barr virus (EBV) contributes to the growth and survival of Hodgkin lymphoma (HL) cells. Here we report that down… 
2008
2008
PTPRK negatively regulates transcriptional activity of wild type and mutated oncogenic beta-catenin and affects membrane distribution of beta-catenin/E-cadherin complexes in cancer cells.
Highly Cited
2006
Highly Cited
2006
Oxidative Inhibition of Receptor-type Protein-tyrosine Phosphatase κ by Ultraviolet Irradiation Activates Epidermal Growth Factor Receptor in Human Keratinocytes*
Ultraviolet (UV) irradiation rapidly increases tyrosine phosphorylation (i.e. activates) of epidermal growth factor receptors… 
2006
2006
Identification of target proteins of N‐acetylglucosaminyl transferase V in human colon cancer and implications of protein tyrosine phosphatase kappa in enhanced cancer cell migration
To gain a better understanding of the mechanism underlying colon cancer and to search for potential markers of colon cancer… 
2005
2005
Transforming growth factor {beta} (TGF-{beta})-Smad target gene protein tyrosine phosphatase receptor type kappa is required for TGF-{beta} function.
Transforming growth factor beta (TGF-beta) inhibits proliferation and promotes cell migration. In TGF-beta-treated MCF10A mammary… 
Highly Cited
2003
Highly Cited
2003
Identification of a Mutated Receptor-Like Protein Tyrosine Phosphatase κ as a Novel, Class II HLA-Restricted Melanoma Antigen1
Recent studies increasingly point to a pivotal role of CD4+ T cells in human anti-tumor immune response. Here we show that… 
Highly Cited
1996
Highly Cited
1996
Association of Human Protein-tyrosine Phosphatase κ with Members of the Armadillo Family*
We have identified a human receptor-like protein-tyrosine phosphatase (PTP) in the mammary carcinoma cell line SK-BR-3, which… 
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