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PTPRC protein, human

Known as: protein tyrosine phosphatase, receptor type C protein, human, CD45, T200 Glycoprotein 
Receptor-type tyrosine-protein phosphatase C (1304 aa, ~147 kDa) is encoded by the human PTPRC gene. This protein plays a role in protein… 
National Institutes of Health

Related topics

Related topics

15 relations

Broader (1)

CD45 Antigens
DephosphorylationEnzyme GeneEsterase GeneHydrolase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2002
2002
CD45 Controls Interleukin-4-mediated IgE Class Switch Recombination in Human B Cells through Its Function as a Janus Kinase Phosphatase*
CD45 plays a critical regulatory role in receptor signaling through its protein tyrosine phosphatase and Janus kinase (JAK… 
2002
2002
A novel mutation in PTPRC interferes with splicing and alters the structure of the human CD45 molecule
Abstract. CD45, encoded by the protein tyrosine phosphatase receptor type C (PTPRC) gene, is essentially involved in maturation… 
Highly Cited
1989
Highly Cited
1989
Definition of the thymic generative lineage by selective expression of high molecular weight isoforms of CD45 (T200)
Selective expression of CD45 isoforms distinguishes naive and memory T cells in peripheral blood. Paradoxically, although the… 
Highly Cited
1989
Highly Cited
1989
Transitions from high to low molecular weight isoforms of CD45 (T200) involve rapid activation of alternate mRNA splicing and slow turnover of surface CD45R.
The expression of CD45 isoforms and of CDw29 has been analyzed as a function of time by correlating cell surface phenotype with… 
Highly Cited
1988
Highly Cited
1988
CD45 regulates signal transduction and lymphocyte activation by specific association with receptor molecules on T or B cells.
Evidence is presented that the leukocyte common antigen CD45 can regulate both signal transduction by lymphocyte receptor… 
Highly Cited
1988
Highly Cited
1988
Loss of CD45R (Lp220) represents a post-thymic T cell differentiation event.
CD45R+ and CDw29+ CD4+ T cells are widely regarded as separate functionally defined T cell lineages. The work described here… 
Highly Cited
1987
Highly Cited
1987
Antibodies to the common leukocyte antigen (T200) inhibit an early phase in the activation of resting human B cells.
T191, a monoclonal antibody reactive with the T200 common leukocyte antigen, profoundly inhibits an early event(s) associated… 
Highly Cited
1985
Highly Cited
1985
Functional modifications of cytotoxic T-lymphocyte T200 glycoprotein recognized by monoclonal antibodies
Plasma membrane glycoproteins of cytotoxic T lymphocytes (CTLs) are involved in the binding to and subsequent destruction of… 
1985
1985
Novel antigenic determinants of the T200 glycoprotein expressed preferentially by activated cytotoxic T lymphocytes.
This report describes the production and characterization of MAb specific for neoantigenic determinants, called CT antigens… 
Highly Cited
1978
Highly Cited
1978
Participation of histocompatibility antigens in capping of molecularly independent cell surface components by their specific antibodies.
The antibody-induced capping of several cell surface components has been investigated by immunofluorescence methods using two… 
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