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PTPN1 wt Allele

Known as: PTP-1B, PTP1B, Protein Tyrosine Phosphatase, Non-Receptor Type 1 wt Allele 
Human PTPN1 wild-type allele is located within 20q13.1-q13.2 and is approximately 74 kb in length. This allele, which encodes tyrosine-protein… 
National Institutes of Health

Related topics

Related topics

11 relations
20q13.1-q13.2Cell Differentiation processCell ProliferationDephosphorylation

Broader (1)

PTPN1 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
New preaustinoids from a marine-derived fungal strain Penicillium sp. SF-5497 and their inhibitory effects against PTP1B activity
Chemical investigation of the marine-derived fungal isolate Penicillium sp. SF-5497 resulted in the isolation of two new… 
2016
2016
Association of PTP1B with Outcomes of Breast Cancer Patients Who Underwent Neoadjuvant Chemotherapy
PTP1B is involved in the oncogenesis of breast cancer. In addition, neoadjuvant therapy has been widely used in breast cancer… 
2014
2014
2,4-Dihydroxychalcone derivatives as novel potent cell division cycle 25B phosphatase inhibitors and protein tyrosine phosphatase 1B inhibitors.
Eleven 2,4-dihydroxychalcone compounds were synthesized and identified as reversible and competitive cell division cycle 25… 
2014
2014
Potent CDC25B and PTP1B phosphatase inhibitors: 2′,4′,6′-trihydroxylchalcone derivatives
In this study, we examined a series of 2′,4′,6′-trihydroxychalcone derivatives for their inhibitory activity as inhibitors of… 
2013
2013
PTP1B is highly induced in the presence of metformin and HCV.
Highly Cited
2013
Highly Cited
2013
Thiol-dependent recovery of catalytic activity from oxidized protein tyrosine phosphatases.
Protein tyrosine phosphatases (PTPs) play an important role in the regulation of mammalian signal transduction. During some cell… 
2005
2005
Regulation of the catalytic activity of PTP1B: roles for cell adhesion, tyrosine residue 66, and proline residues 309 and 310.
2004
2004
Protein-tyrosine phosphatase 1B associates with insulin receptor and negatively regulates insulin signaling without receptor internalization.
Phosphorylated platelet-derived growth factor (PDGF) receptor becomes internalized and then is dephosphorylated by protein… 
2004
2004
trans-Beta-nitrostyrene derivatives as slow-binding inhibitors of protein tyrosine phosphatases.
Protein tyrosine phosphatases (PTPs) catalyze the hydrolysis of phosphotyrosyl (pY) proteins to produce tyrosyl proteins and… 
Highly Cited
2000
Highly Cited
2000
Assessment of Protein-tyrosine Phosphatase 1B Substrate Specificity Using “Inverse Alanine Scanning”*
An “inverse alanine scanning” peptide library approach has been developed to assess the substrate specificity of protein-tyrosine… 
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