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PTPN1 wt Allele

Known as: PTP-1B, PTP1B, Protein Tyrosine Phosphatase, Non-Receptor Type 1 wt Allele 
Human PTPN1 wild-type allele is located within 20q13.1-q13.2 and is approximately 74 kb in length. This allele, which encodes tyrosine-protein… Expand
National Institutes of Health

Related topics

Related topics

11 relations
20q13.1-q13.2Cell Differentiation processCell ProliferationDephosphorylation
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Broader (1)

PTPN1 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
The insulin-mimetic effect of Morin: a promising molecule in diabetes treatment.
BACKGROUND Type-2 diabetes is a worldwidely diffuse disease characterized by insulin resistance that arises from alterations of… Expand
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2013
2013
Bioactive carbazole alkaloids from Murraya koenigii (L.) Spreng.
Four new carbazole alkaloids (1-4) and fourteen known carbazole alkaloids (5-18) were isolated from Murraya koenigii. Their… Expand
Highly Cited
2012
Highly Cited
2012
PTP1B is an androgen receptor-regulated phosphatase that promotes the progression of prostate cancer.
The androgen receptor (AR) signaling axis plays a key role in the pathogenesis of prostate cancer. In this study, we found that… Expand
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Highly Cited
2010
Highly Cited
2010
Inhibition of acid, alkaline, and tyrosine (PTP1B) phosphatases by novel vanadium complexes.
In the course of our investigations of vanadium-containing complexes for use as insulin-enhancing agents, we have generated a… Expand
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Review
2007
Review
2007
Inhibition of the protein tyrosine phosphatase PTP1B: potential therapy for obesity, insulin resistance and type-2 diabetes mellitus.
The global epidemic of obesity and type-2 diabetes mellitus (T2DM) has highlighted the need for new therapeutic approaches. The… Expand
2005
2005
PTP1B inhibitors from Ardisia japonica
In bioassay-directed isolation from the whole plant of Ardisia japonica, sixteen known compounds: chrysophanol (1), physcion (2… Expand
Highly Cited
2002
Highly Cited
2002
PTP1B regulates leptin signal transduction in vivo.
Mice lacking the protein-tyrosine phosphatase PTP1B are hypersensitive to insulin and resistant to obesity. However, the… Expand
2002
2002
The structure of PTP-1B in complex with a peptide inhibitor reveals an alternative binding mode for bisphosphonates.
Inhibitors of PTP-1B could be therapeutically beneficial in the treatment of type 2 diabetes. Owing to the large number of… Expand
Highly Cited
1997
Highly Cited
1997
Protein-tyrosine Phosphatases PTP1B and Syp Are Modulators of Insulin-stimulated Translocation of GLUT4 in Transfected Rat Adipose Cells*
The protein-tyrosine phosphatases PTP1B and Syp have both been implicated as modulators of the mitogenic actions of insulin… Expand
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Highly Cited
1997
Highly Cited
1997
Improved sensitivity to insulin in obese subjects following weight loss is accompanied by reduced protein-tyrosine phosphatases in adipose tissue.
Insulin resistance in adipose tissue in human obesity is associated with increased protein-tyrosine phosphatase (PTPase) activity… Expand
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