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PTPN1 gene

Known as: PTP1B, Protein Tyrosine Phosphatase, Non-Receptor Type 1 Gene, PTPN1 
This gene plays a role in the regulation of insulin signaling and inhibition of cell growth.
National Institutes of Health

Papers overview

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Highly Cited
2018
Highly Cited
2018
BACKGROUND Synaptic loss is an early pathological event in Alzheimer's disease (AD), but its underlying molecular mechanisms… Expand
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Highly Cited
2014
Highly Cited
2014
Classical Hodgkin lymphoma and primary mediastinal B cell lymphoma (PMBCL) are related lymphomas sharing pathological, molecular… Expand
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Highly Cited
2013
Highly Cited
2013
Neuropilin 1 (NRP1) plays an important but ill-defined role in VEGF-A signaling and vascular morphogenesis. We show that mice… Expand
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Highly Cited
2013
Highly Cited
2013
Colorectal cancer (CRC) is one of the leading causes of cancer deaths in Western countries. A significant number of CRC patients… Expand
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2010
2010
Insulin is an inducer of brown fat adipogenesis through the activation of a signalling network that involves positive/negative… Expand
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2009
2009
Abstract Protein tyrosine kinases have important roles in spermatozoa; however, little is known about the presence and regulation… Expand
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2005
2005
BackgroundThe protein tyrosine phosphatase-1B, a negative regulator for insulin and leptin signalling, potentially modulates… Expand
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2005
2005
Protein tyrosine phosphatase (PTP)-1B, encoded by the PTPN1 gene, inactivates the insulin signal transduction cascade by… Expand
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Highly Cited
1998
Highly Cited
1998
ABSTRACT The p210 bcr-abl protein tyrosine kinase (PTK) appears to be directly responsible for the initial manifestations of… Expand
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Highly Cited
1997
Highly Cited
1997
The protein-tyrosine phosphatases PTP1B and Syp have both been implicated as modulators of the mitogenic actions of insulin… Expand
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