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PTGES wt Allele

Known as: PGES, Prostaglandin E Synthase wt Allele, PIG12 
Human PTGES wild-type allele is located in the vicinity of 9q34.3 and is approximately 15 kb in length. This allele, which encodes prostaglandin E… 
National Institutes of Health

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Oxidation-Reduction

Papers overview

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Highly Cited
2010
Highly Cited
2010
Identification of Key Residues Determining Species Differences in Inhibitor Binding of Microsomal Prostaglandin E Synthase-1*
Microsomal prostaglandin E synthase-1 (MPGES1) is induced during an inflammatory reaction from low basal levels by pro… 
2010
2010
The Molecular Pharmacology and In Vivo Activity of 2-(4-Chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid (YS121), a Dual Inhibitor of Microsomal Prostaglandin E2 Synthase-1 and 5…
The microsomal prostaglandin E2 synthase (mPGES)-1 is one of the terminal isoenzymes of prostaglandin (PG) E2 biosynthesis… 
2007
2007
Consequences of altered eicosanoid patterns for nociceptive processing in mPGES-1-deficient mice
Cyclooxygenase‐2 (COX‐2)‐dependent prostaglandin (PG) E2 synthesis in the spinal cord plays a major role in the development of… 
Highly Cited
2003
Highly Cited
2003
In vitro effects of eicosanoids derived from different 20‐carbon fatty acids on T helper type 1 and T helper type 2 cytokine production in human whole‐blood cultures
Background Different series prostaglandins (PGs) and leukotrienes (LTs) are synthesized from different 20 carbon fatty acid… 
Highly Cited
1984
Highly Cited
1984
Stimulus specificity of prostaglandin inhibition of rabbit polymorphonuclear leukocyte lysosomal enzyme release and superoxide anion production.
Prostaglandins (PGs) of the E series and PGI2 have been shown to inhibit acute inflammatory reactions in vivo and… 
Highly Cited
1981
Highly Cited
1981
Anti-PGE antibodies inhibit in vivo development of cell-mediated immunity
Prostaglandins have been implicated in the regulation of humoral and cell-mediated (CMI) immunity, but little is known about… 
Highly Cited
1979
Highly Cited
1979
Prostaglandin E modulation of the mitogenic response of human T cells. Differential response of T-cell subpopulations.
Prostaglandins (PG) of the E series, PGE(1) and PGE(2) (PGEs), can induce elevations of intracellular cyclic AMP (cAMP) among… 
Highly Cited
1974
Highly Cited
1974
Inhibitory effect of prostaglandins on isosmotic fluid transport by rabbit gall-bladder in vitro, and its modification by blocade of endogenous PGE-Biosynthesis with indomethacin.
In the presence of indomethacin serosal application of PGEi and PGE2 caused significant inhibition of net isosmotic fluid… 
1971
1971
INTERACTION OF E PROSTAGLANDINS AND SYNTOCINON ON THE PREGNANT HUMAN MYOMETRIUM
The possibility that ketonic prostaglandins (PGEs) and oxytocin (Syntocinon, Sandoz) may be used to supplement each other on the… 
Highly Cited
1968
Highly Cited
1968
A simple chemical procedure for distinguishing E from F prostaglandins, with application to tissue extracts.
An easy and relatively rapid procedure for distinguishihg the ketonic prostaglandins E (PGEs) from the nonketonic… 
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