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PTGER2 gene

Known as: EP2, prostaglandin E receptor 2, PTGER2 
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
EP2 and EP4 Receptors Regulate Aromatase Expression in Human Adipocytes and Breast Cancer Cells
Cytochrome P450 aromatase (aromatase), a product of the CYP19 gene, catalyzes the synthesis of estrogens from androgens. Because… 
2008
2008
Prostanoid receptor EP1 expression in breast cancer
Cyclooxygenase enzymes play an important role in carcinogenesis, and increased expression of cyclooxygenase enzymes has been… 
2008
2008
Soluble EP2 neutralizes prostaglandin E2–induced cell signaling and inhibits osteolytic tumor growth
Prostaglandin E2 (PGE2) plays a key role in osteolytic bone metastasis as well as roles in inflammation, cell growth, and tumor… 
2007
2007
Roles of cyclooxygenase-2 and prostaglandin E receptors in gastric mucosal defense in Helicobacter pylori-infected mice
Abstract.Background/Aim:Helicobacter pylori (H. pylori) induces cyclooxygenase-2 (COX-2) expression. The aim of this study was to… 
2006
2006
A rancid culprit in vascular inflammation acts on the prostaglandin receptor EP2.
See related article, pages 642–650 Although our knowledge about the mechanisms underlying atherosclerosis and its complications… 
Review
2005
Review
2005
Microglial EP2 as a new target to increase amyloid beta phagocytosis and decrease amyloid beta-induced damage to neurons.
Epidemiologic and animal model data support a role for the prostaglandin pathway in AD pathogenesis. However, unexpected toxicity… 
2005
2005
Cyclooxygenase-2-dependent prostaglandin (PG) E2 downregulates matrix metalloproteinase-3 production via EP2/EP4 subtypes of PGE2 receptors in human periodontal ligament cells stimulated with…
BACKGROUND Prostaglandin E2 (PGE2), which exerts its actions via EP receptors (EP1, EP2, EP3, and EP4), is a bioactive metabolite… 
1994
1994
Possible involvement of the EP2 receptor subtype in PGE2-induced enhancement of the heat response of nociceptors
1993
1993
Stimulatory (EP1 and EP3) and inhibitory (EP2) prostaglandin E2 receptors in isolated ileal smooth muscle cells.
1990
1990
EP3, but not EP2, FP, or TP prostanoid-receptor stimulation may reduce intraocular pressure.
Stimulation of DP, but not TP or FP, prostanoid receptors has previously been shown to reduce intraocular pressure (IOP) in… 
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