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PTEN protein, human

Known as: Phosphatidylinositol-3,4,5-Trisphosphate 3-Phosphatase and Dual-Specificity Protein Phosphatase PTEN, phosphatase and tensin homolog protein, human, MMAC1 protein, human 
Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (403 aa, ~47 kDa) is encoded by the human PTEN… 
National Institutes of Health

Related topics

Related topics

18 relations
CTCF PathwayDUSP10 protein, humanDephosphorylationEnzyme Gene

Broader (1)

PTEN Phosphohydrolase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2008
Review
2008
Understanding PTEN regulation: PIP2, polarity and protein stability
The PTEN tumour suppressor is a lipid and protein phosphatase that inhibits phosphoinositide 3-kinase (PI3K)-dependent signalling… 
Highly Cited
2007
Highly Cited
2007
Ubiquitination Regulates PTEN Nuclear Import and Tumor Suppression
Highly Cited
2005
Highly Cited
2005
Mitochondrial H2O2 Regulates the Angiogenic Phenotype via PTEN Oxidation*
Recent studies have demonstrated that the tumor suppressor PTEN (phosphatase and tensin homolog deleted from chromosome 10), the… 
Review
2004
Review
2004
Human cancer, PTEN and the PI-3 kinase pathway.
Highly Cited
2004
Highly Cited
2004
Thioredoxin-1 binds to the C2 domain of PTEN inhibiting PTEN's lipid phosphatase activity and membrane binding: a mechanism for the functional loss of PTEN's tumor suppressor activity.
Highly Cited
2003
Highly Cited
2003
Src Family Protein-tyrosine Kinases Alter the Function of PTEN to Regulate Phosphatidylinositol 3-Kinase/AKT Cascades*
Src family protein-tyrosine kinases, which play an important role in signal integration, have been implicated in tumorigenesis in… 
Highly Cited
2003
Highly Cited
2003
Allosteric Activation of PTEN Phosphatase by Phosphatidylinositol 4,5-Bisphosphate*
Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) is a tumor suppressor that is lost in many human tumors and… 
Highly Cited
2001
Highly Cited
2001
The Tumor Suppressor PTEN Is Phosphorylated by the Protein Kinase CK2 at Its C Terminus
The tumor suppressor phosphatase PTEN regulates cell migration, growth, and survival by dephosphorylating phosphatidylinositol… 
Highly Cited
2001
Highly Cited
2001
Phosphorylation of the PTEN Tail Acts as an Inhibitory Switch by Preventing Its Recruitment into a Protein Complex*
PTEN is a tumor suppressor protein that functions, in large part, by dephosphorylating the lipid second messenger… 
Highly Cited
1999
Highly Cited
1999
PTEN is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanismsin haematological malignancies.
PTEN is a novel tumour suppressor gene that encodes a dual-specificity phosphatase with homology to adhesion molecules tensin and… 
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