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PTEN Phosphohydrolase

Known as: Mutated In Multiple Advanced Cancers 1 Protein, Phosphatase, PTEN, Protein Phosphatase, PTEN 
A lipid phosphatase that contains a C2 DOMAIN and acts on phosphatidylinositol-3,4,5-trisphosphate to regulate various SIGNAL TRANSDUCTION PATHWAYS… Expand
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
PURPOSE Analytically validated assays to interrogate biomarker status in clinical samples are crucial for personalized medicine… Expand
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Highly Cited
2010
Highly Cited
2010
Regulated protein degradation via the ubiquitin-proteasome system (UPS) plays a central role in building synaptic connections… Expand
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Highly Cited
2010
Highly Cited
2010
BACKGROUND Resveratrol, a naturally occurring phytopolyphenol compound, has attracted extensive interest in recent years because… Expand
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Highly Cited
2010
Highly Cited
2010
PTEN is a tumour suppressor with phosphatase activity in vitro against both lipids and proteins and other potential non-enzymatic… Expand
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Highly Cited
2008
Highly Cited
2008
The product of the Snail1 gene is a transcriptional repressor required for triggering the epithelial-to-mesenchymal transition… Expand
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Highly Cited
2007
Highly Cited
2007
Pathway-specific therapy is the future of cancer management. The oncogenic phosphatidylinositol 3-kinase (PI3K) pathway is… Expand
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Highly Cited
2005
Highly Cited
2005
Pten-/- cells display a partially defective checkpoint in response to ionizing radiation (IR). The checkpoint defect was traced… Expand
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Review
2002
Review
2002
Germline mutations distributed across the PTEN tumor-suppressor gene have been found to result in a wide spectrum of phenotypic… Expand
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2000
2000
Recently, a putative tumor suppressor gene, PTEN/MMAC1, has been identified at chromosome 10q23.3, which encodes a 403 amino acid… Expand
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Highly Cited
1999
Highly Cited
1999
Understanding the functional roles of the molecular alterations that are involved in the oncogenesis of prostate cancer, the… Expand
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