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PTEN Loss
A molecular abnormality referring to the loss of at least one copy of the PTEN gene (10q23).
National Institutes of Health
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PTEN gene
Papers overview
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2016
2016
Aberrant NHERF1 expression as a biomarker in lung carcinoma
D. Belchis
,
N. Cuka
,
N. Sharma
,
Rajni B. Sharma
,
C. Gocke
2016
Corpus ID: 5296225
Abstract Background: Na/H exchange regulator factor 1 (NHERF1/EBP50) isan adaptor/signaling protein that when aberrantly…
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2011
2011
Abstract 4854: Mutations activating proliferation pathways in ovarian cancer
N. Uhrhammer
,
Y. Bidet
,
+5 authors
Y. Bignon
2011
Corpus ID: 75493150
Ovarian malignancies may arise through different mechanisms of oncogenesis, which influence their treatment and are important for…
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2011
2011
PD09-05: SU2C Phase Ib Study of pan-PI3K Inhibitor BKM120 Plus Aromatase Inhibitor Letrozole in ER+/HER2− Metastatic Breast Cancer (MBC).
I. Mayer
,
J. Balko
,
+5 authors
C. Arteaga
2011
Corpus ID: 57204022
Background: Experimental evidence and clinical data suggest that PIK3CA mutations (present in approximately 35% of ER+ cancers…
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2010
2010
Pten INACTIVATION PROMOTES LOSS OF MYC ''ONCOGENE ADDICTION'' IN A CONDITIONAL ZEBRAFISH MODEL OF T-ALL
A. Gutierrez
,
Ruta Grebliunaite
,
+5 authors
T. Look
2010
Corpus ID: 86209284
Background: Some but not all experimental MYC-induced tumors are dependent on ongoing MYC activity for maintenance of the tumor…
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Review
2006
Review
2006
MouseModeling in Oncologic Preclinical andTranslational Research
B. Carver
,
P. Pandolfi
2006
Corpus ID: 21078389
Through scientific and technological advancements, our ability to manipulate the mouse genome has allowed us to evaluate the…
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