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PTEN Loss

A molecular abnormality referring to the loss of at least one copy of the PTEN gene (10q23).
National Institutes of Health

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PTEN gene

Papers overview

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2018
2018
Association of phosphatidylinositol 3-kinase (PI3K) pathway activation with increased immune checkpoint expression in colorectal cancer (CRC) patients.
653Background: PI3K pathway is a known modulator of anti-tumor immune response and is frequently activated in CRC through genetic… 
2018
2018
Abstract 5499: A potent BH3 mimetic targeting BCL-XLinduces apoptosis regulated by PTEN loss and integrin alpha 5 in prostate cancer cells
Background: PTEN-loss is a highly prevalent genomic event associated with higher risk of metastatic progression and resistance to… 
Review
2015
Review
2015
Upfront molecular testing in patients with advanced gastro-esophageal cancer: Is it time yet?
Introduction Targeting HER2 has improved outcomes in metastatic GE (mGE) cancer. In this study, we aim to explore the feasibility… 
2013
2013
Abstract 48: Theranostic profiling of adolescents and young adults (AYA) with advanced fibrolamellar hepatocellular carcinoma identifies aberrant activation of the PI3K/AKT/MTOR signaling cascade.
Background: Fibrolamellar hepatocellular carcinoma (FLHCC) is an extremely rare malignancy predominantly affecting adolescents… 
2011
2011
Abstract LB-102: Inhibiting the expansion of hepatic cancer stem cells by targeting β-catenin/CBP interaction with ICG-001 in liver Pten deficient mice
We used a liver specific Pten (phosphatase and tensin homologue deleted on chromosome ten) deletion murine model to investigate… 
2011
2011
A phase II neoadjuvant trial of concurrent trastuzumab and paclitaxel without anthracycline in women with HER2-positive operable breast cancer.
283 Background: Neoadjuvant paclitaxel plus trastuzumab followed by 5-fluorouracil, epirubicin, and cyclophosphamide plus… 
2011
2011
A phase II neoadjuvant trial of concurrent trastuzumab and paclitaxel without anthracycline in women with HER2-positive operable breast cancer.
e11070 Background: Neoadjuvant paclitaxel plus trastuzumab followed by 5-fluorouracil, epirubicin, and cyclophosphamide plus… 
2011
2011
Abstract 4854: Mutations activating proliferation pathways in ovarian cancer
Ovarian malignancies may arise through different mechanisms of oncogenesis, which influence their treatment and are important for… 
2010
2010
Pten INACTIVATION PROMOTES LOSS OF MYC ''ONCOGENE ADDICTION'' IN A CONDITIONAL ZEBRAFISH MODEL OF T-ALL
Background: Some but not all experimental MYC-induced tumors are dependent on ongoing MYC activity for maintenance of the tumor… 
2010
2010
The clinicopathologic values of the molecules associated with the main pathogenesis of the glioblastoma
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