PT-141

 
National Institutes of Health

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bremelanotide

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2007
2007
Melanocortin receptors, melanotropic peptides and penile erection.
Penile erection is a complex physiologic event resulting from the interactions of the nervous system on a highly specialized… (More)
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Review
2007
Review
2007
Melanocortins in the treatment of male and female sexual dysfunction.
Melanocortinergic agents are currently being investigated for a possible therapeutic role in male and female sexual dysfunction… (More)
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2006
2006
An effect on the subjective sexual response in premenopausal women with sexual arousal disorder by bremelanotide (PT-141), a melanocortin receptor agonist.
INTRODUCTION Melanocortins affect multiple physiological responses, including sexual behaviors. Bremelanotide is a synthetic… (More)
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2005
2005
Co-administration of low doses of intranasal PT-141, a melanocortin receptor agonist, and sildenafil to men with erectile dysfunction results in an enhanced erectile response.
OBJECTIVES To evaluate the safety and pharmacodynamic effect of co-administration of subtherapeutic doses of PT-141, a cyclic… (More)
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2005
2005
Gateways to clinical trials.
Gateways to Clinical Trials are a guide to the most recent clinical trials in current literature and congresses. The data in the… (More)
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2004
2004
Double-blind, placebo-controlled evaluation of the safety, pharmacokinetic properties and pharmacodynamic effects of intranasal PT-141, a melanocortin receptor agonist, in healthy males and patients…
PT-141, a cyclic heptapeptide melanocortin analog, was evaluated following intranasal administration in healthy male subjects and… (More)
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2004
2004
Evaluation of the safety, pharmacokinetics and pharmacodynamic effects of subcutaneously administered PT-141, a melanocortin receptor agonist, in healthy male subjects and in patients with an…
PT-141, a cyclic heptapeptide melanocortin analog, was evaluated following subcutaneous administration to healthy male subjects… (More)
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2004
2004
Selective facilitation of sexual solicitation in the female rat by a melanocortin receptor agonist.
Disorders of sexual desire affect an estimated 30% of women in North America and Europe, with etiologies based on interpersonal… (More)
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2004
2004
Statins: Target audience
The considerable success of phosphodiesterase 5 inhibitors, such as sildenafil (Viagra; Pfizer), in the treatment of erectile… (More)
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2003
2003
PT-141: a melanocortin agonist for the treatment of sexual dysfunction.
PT-141, a synthetic peptide analogue of alpha-MSH, is an agonist at melanocortin receptors including the MC3R and MC4R, which are… (More)
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