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PRKCQ gene

Known as: PRKCQ, PROTEIN KINASE C, THETA, protein kinase C theta 
National Institutes of Health

Papers overview

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2010
2010
Widespread Expression of PICOT in Mouse and Human Tissues With Predominant Localization to Epithelium
The protein kinase C-interacting cousin of thioredoxin (PICOT; also termed glutaredoxin 3) protein was discovered a decade ago as… 
2008
2008
Identification, characterization and initial hit-to-lead optimization of a series of 4-arylamino-3-pyridinecarbonitrile as protein kinase C theta (PKCtheta) inhibitors.
The protein kinase C (PKC) family of serine/threonine kinases is implicated in a wide variety of cellular processes. The PKC… 
2008
2008
Regulated Movement of CD4 In and Out of the Immunological Synapse1
The mechanism underlying the transient accumulation of CD4 at the immunological synapse (IS) and its significance for T cell… 
2008
2008
Sequestration of NF-κB Signaling Complexes in Lipid Rafts Contributes to Repression of NF-κB in T Lymphocytes under Hyperthermia Stress*
Sepsis causes extensive apoptosis of lymphocytes, a pathological condition that is frequently associated with hyperthermia. Heat… 
2008
2008
Primary Clearance of Murine Gammaherpesvirus 68 by PKCθ−/− CD8 T Cells Is Compromised in the Absence of Help from CD4 T Cells
ABSTRACT CD4 T cells are dispensable for acute control of murine gammaherpesvirus 68 (MHV-68) but are necessary for effective… 
2006
2006
Involvement of GATA3 in protein kinase C theta-induced Th2 cytokine expression.
Protein kinase C theta (PKCtheta) is essential for T cell activation, as it is required for the activation of NF-kappaB and… 
2005
2005
Protein kinase C theta is not essential for T-cell-mediated clearance of murine gammaherpesvirus 68.
Murine gammaherpesvirus 68 (MHV-68) is a naturally occurring rodent pathogen with significant homology to human pathogens Epstein… 
Review
2002
Review
2002
Determining the destiny of NF-kappa B after TCR ligation: it's CARMA1.
In T lymphocytes, the "novel" protein kinase C theta (PKC theta) isoform and the transcription factor nuclear factor-kappaB (NF… 
2001
2001
Protein kinase C theta cooperates with Vav1 to induce JNK activity in T-cells.
Here we show that in human T-cell leukemia cells Vav1 and protein kinase C theta (PKCtheta) synergize for the activation of c-Jun… 
Highly Cited
1996
Highly Cited
1996
Direct interaction between protein kinase C theta (PKC theta) and 14-3-3 tau in T cells: 14-3-3 overexpression results in inhibition of PKC theta translocation and function
Recent studies have documented direct interactions between 14-3-3 proteins and several oncogene and proto-oncogene products… 
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