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PRKACA gene

Known as: protein kinase cAMP-activated catalytic subunit alpha, PRKACA, PKACa 
This gene is involved in the regulation of diverse cell processes including cell growth, proliferation, differentiation and motility.
National Institutes of Health

Related topics

Related topics

6 relations
PRKACA protein, humanPRKACA wt AllelePhosphorylationSerine/Threonine Phosphorylation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Lipofuscin Accumulation in Cortisol-Producing Adenomas With and Without PRKACA Mutations
Abstract The adrenal cortex accumulates lipofuscin granules with age. Lipofuscin accumulation is also seen in adrenocortical… 
2016
2016
Double adrenocortical adenomas harboring independent KCNJ5 and PRKACA somatic mutations.
OBJECTIVE Co-secretion of cortisol and aldosterone can be observed in adrenal adenomas. The aim of this study was to investigate… 
Review
2015
Review
2015
Genetics of adrenal diseases in 2014: Genetics improves understanding of adrenocortical tumours
2014 has seen advances in our understanding of benign and malignant tumours of the adrenal cortex, particularly in Cushing… 
Review
2015
Review
2015
Phosphodiesterase 8B and cyclic AMP signaling in the adrenal cortex
Bilateral adrenocortical hyperplasia (BAH) in humans and mice has been recently linked to phosphodiesterase (PDE) 8B (PDE8B) and… 
2014
2014
Role of Calmodulin-Calmodulin Kinase II, cAMP/Protein Kinase A and ERK 1/2 on Aeromonas hydrophila-Induced Apoptosis of Head Kidney Macrophages
The role of calcium (Ca2+) and its dependent protease calpain in Aeromonas hydrophila-induced head kidney macrophage (HKM… 
2014
2014
E pluribus unum? The main protein kinase A catalytic subunit (PRKACA), a likely oncogene, and cortisol-producing tumors.
Evidence has been accumulating for years that increased cAMP signaling (Figure 1) is the culprit behind the development of most… 
2014
2014
Neuroendocrine cancer: An activating hotspot mutation in PRKACA provides clues for adrenal Cushing syndrome therapeutics
An activating hotspot mutation in PRKACA provides clues for adrenal Cushing syndrome therapeutics New genetic findings might have… 
2013
2013
Involvement of spinal PKA/CREB signaling pathway in the development of bone cancer pain
2010
2010
Gene expression profiles of adipose tissue of high-fat diet-induced obese rats by cDNA microarrays
To better understand the molecular basis of dietary obesity, we examined adipose tissue genes differentially expressed in a well… 
2008
2008
CDC25B Acts as a Potential Target of PRKACA in Fertilized Mouse Eggs1
Abstract Protein kinase A (PRKACA) has been documented as a pivotal regulator in meiosis and mitosis arrest. Although our… 
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