PRDX3 gene

Known as: MER5, PRX3, AOP-1 
 
National Institutes of Health

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PRDX3 peroxidase

Papers overview

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2013
2013
Hyperoxidation of peroxiredoxins 2 and 3: rate constants for the reactions of the sulfenic acid of the peroxidatic cysteine.
Typical 2-Cys peroxiredoxins (Prxs) react rapidly with H2O2 to form a sulfenic acid, which then condenses with the resolving… (More)
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2013
2013
MiR-383 is downregulated in medulloblastoma and targets peroxiredoxin 3 (PRDX3).
Accumulating evidence suggests that microRNAs (miRNAs) are over- or under-expressed in tumors, and abnormalities in miRNA… (More)
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2011
2011
Mitochondria-targeted antioxidants protect pancreatic β-cells against oxidative stress and improve insulin secretion in glucotoxicity and glucolipotoxicity.
Mitochondrial oxidative damage is thought to play a key role in pancreatic β-cell failure in the pathogenesis of type 2 diabetes… (More)
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2011
2011
Model for the exceptional reactivity of peroxiredoxins 2 and 3 with hydrogen peroxide: a kinetic and computational study.
Peroxiredoxins (Prx) are thiol peroxidases that exhibit exceptionally high reactivity toward peroxides, but the chemical basis… (More)
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Review
2010
Review
2010
Copper transporters and the cellular pharmacology of the platinum-containing cancer drugs.
Multiple lines of evidence indicate that the platinum-containing cancer drugs enter cells, are distributed to various subcellular… (More)
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2010
2010
Maternal Undernutrition Significantly Impacts Ovarian Follicle Number and Increases Ovarian Oxidative Stress in Adult Rat Offspring
BACKGROUND We have shown recently that maternal undernutrition (UN) advanced female pubertal onset in a manner that is dependent… (More)
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Highly Cited
2008
Highly Cited
2008
The thioredoxin reductase inhibitor auranofin triggers apoptosis through a Bax/Bak-dependent process that involves peroxiredoxin 3 oxidation.
Thioredoxin reductase (TrxR) is a key selenoprotein antioxidant enzyme and a potential target for anti-cancer drugs. One potent… (More)
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2003
2003
Enhancement of mitochondrial oxidative stress and up-regulation of antioxidant protein peroxiredoxin III/SP-22 in the mitochondria of human pre-eclamptic placentae.
A growing body of evidence indicates that the pathogenesis of pre-eclampsia is closely associated with oxidative stress occurring… (More)
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Highly Cited
2001
Highly Cited
2001
Gene duplication in the diversification of secondary metabolism: tandem 2-oxoglutarate-dependent dioxygenases control glucosinolate biosynthesis in Arabidopsis.
Secondary metabolites are a diverse set of plant compounds believed to have numerous functions in plant-environment interactions… (More)
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2001
2001
Abrin triggers cell death by inactivating a thiol-specific antioxidant protein.
Abrin A-chain (ABRA) inhibits protein synthesis by its N-glycosidase activity as well as induces apoptosis, but the molecular… (More)
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