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PRDM16 gene

Known as: transcription factor MEL1, KIAA1675, PR domain 16 
This gene plays a role in both transcriptional regulation and adipocyte differentiation.
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
A clear relationship exists between visceral obesity and type 2 diabetes, whereas subcutaneous obesity is comparatively benign… Expand
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Highly Cited
2014
Highly Cited
2014
Prdm16 is a transcription factor that regulates the thermogenic gene program in brown and beige adipocytes. However, whether… Expand
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Highly Cited
2013
Highly Cited
2013
Transcriptional effectors of white adipocyte-selective gene expression have not been described. Here we show that TLE3 is a white… Expand
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Highly Cited
2012
Highly Cited
2012
Brown adipose tissue dissipates energy through heat and functions as a defense against cold and obesity. PPARγ ligands have been… Expand
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Highly Cited
2012
Highly Cited
2012
Heterochromatin serves important functions, protecting genome integrity and stabilizing gene expression programs. Although the… Expand
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Highly Cited
2011
Highly Cited
2011
Fetal liver and adult bone marrow hematopoietic stem cells (HSCs) renew or differentiate into committed progenitors to generate… Expand
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Highly Cited
2010
Highly Cited
2010
To better understand the mechanisms that regulate stem cell identity and function, we sought to identify genes that are… Expand
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Highly Cited
2009
Highly Cited
2009
Brown adipose cells are specialized to dissipate chemical energy in the form of heat, as a physiological defence against cold and… Expand
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Highly Cited
2006
Highly Cited
2006
Gene transfer into hematopoietic stem cells has been used successfully for correcting lymphoid but not myeloid immunodeficiencies… Expand
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Highly Cited
2000
Highly Cited
2000
The reciprocal translocation t(1;3)(p36;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML… Expand
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