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Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation
TLDR
HTLV-1 infectivity and how the HTLV- 1 Tax oncoprotein initiates transformation by creating a cellular environment favouring aneuploidy and clastogenic DNA damage are discussed.
HTLV-I basic leucine zipper factor gene mRNA supports proliferation of adult T cell leukemia cells.
TLDR
It is shown that a gene encoded by the minus strand of the HTLV-I proviral genome, HT LV-I basic leucine zipper factor (HBZ), is transcribed from 3'-LTR in all ATL cells, which indicates that the single HBZ gene has bimodal functions in two different molecular forms.
Integrated molecular analysis of adult T cell leukemia/lymphoma
TLDR
The identified alterations overlap significantly with the HTLV-1 Tax interactome and are highly enriched for T cell receptor–NF-κB signaling, T cell trafficking and other T cell–related pathways as well as immunosurveillance.
Human T-cell leukemia virus type 1 (HTLV-1) and leukemic transformation: viral infectivity, Tax, HBZ and therapy
TLDR
Progress is reviewed in the understanding of HTLV-1 infectivity, cellular transformation, anti-sense transcription and therapy, 30 years after the original discovery of this virus.
Genetic and epigenetic inactivation of tax gene in adult T‐cell leukemia cells
TLDR
In ATL cases with genetic changes that could not produce Tax protein, the tax gene was frequently transcribed, suggesting that such cells do not need the transcriptional silencing.
Broad Antiretroviral Activity and Resistance Profile of the Novel Human Immunodeficiency Virus Integrase Inhibitor Elvitegravir (JTK-303/GS-9137)
TLDR
The antiviral activity and resistance profile in vitro of a novel IN inhibitor, elvitegravir (EVG) (also known as JTK-303/GS-9137), currently being developed for the treatment of HIV-1 infection are described, suggesting that IN inhibitors bind to a conformationally conserved region of various retroviral IN enzymes and are an ideal drug for a range of Retroviral infections.
HTLV-1 bZIP Factor Induces T-Cell Lymphoma and Systemic Inflammation In Vivo
TLDR
It is shown that transgenic expression of HBZ in CD4+ T cells induced T-cell lymphomas and systemic inflammation in mice, resembling diseases observed in HTLV-1 infected individuals.
In vivo expression of the HBZ gene of HTLV-1 correlates with proviral load, inflammatory markers and disease severity in HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
TLDR
In vivo expression of HBZ plays a role in HAM/TSP pathogenesis, and the HTLV-1 HBZ, but not tax mRNA load, positively correlated with disease severity and with neopterin concentration in the cerebrospinal fluid of HAM/ TSP patients.
Transcriptional Control of Spliced and Unspliced Human T-Cell Leukemia Virus Type 1 bZIP Factor (HBZ) Gene
TLDR
It is demonstrated that Sp1 is critical for s HBZ transcription, which accounts for the constitutive expression of the sHBZ gene, which plays a significant role in the proliferation of infected cells.
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