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PR-957

Known as: ONX 0914 
National Institutes of Health

Papers overview

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2019
2019
OBJECTIVE To study the effect of PR-957 on the formation of A1 reactive astrocytes. METHODS The cerebral cortices of 1-day-old… 
2017
2017
Analytical methods for the detection of substandard and falsified medical products (SFs) are important for public health and… 
2016
2016
.............................................................................................................................................. 68 Introduction ......................................................................................................................................... 69 Results ................................................................................................................................................. 70 EAE induction in immunoproteasome-deficient mice. ................................................................... 70 An LMP7-selective inhibitor prevents symptoms of EAE. ............................................................... 70 LMP7 inhibition prevents brain and spinal cord inflammation. ...................................................... 72 Therapeutic treatment with ONX 0914 inhibits progression of MOG35-55-induced EAE. ................ 75 ONX 0914 blocks differentiation to autoreactive T cells. ................................................................ 77 ONX 0914 reduces clinical symptoms in the PLP139-15-induced relapsing-remitting EAE model in SJL/J Mice. ....................................................................................................................................... 77 Discussion ............................................................................................................................................ 79 Material and Methods ......................................................................................................................... 82 Supplementary information ................................................................................................................ 87 CHAPTER III: LCMV-INDUCED MENINGITIS ............................................................................ 88 1. Inhibition and deficiency of the immunoproteasome subunit LMP7 attenuates LCMVinduced meningitis ..................................................................................................................... 88 Abstract ............................................................................................................................................... 89.............................................................................................................................................. 89 
2015
2015
Objectives: Proteasome inhibition by bortezomib, a constitutive proteasome inhibitor (PI) approved for the treatment of multiple… 
2015
2015
Astrocytes expressing the aquaporin-4 water channel are a primary target of pathogenic, disease-specific immunoglobulins (IgG… 
2013
2013
Submitted 5 Inactivating PSMB5 mutations and P-glyco-protein (MDR1/ ABCB1) mediate resistance to proteasome inhibitors: ex vivo…