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PPARA gene

Known as: peroxisome proliferator activated receptor alpha, hPPAR, NR1C1 
This gene is involved in ligand-mediated transcriptional regulation.
National Institutes of Health

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Biologic DevelopmentCell Differentiation processCell ProliferationHomeostasis

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PPARA wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Treatment with PPARδ agonist alleviates non-alcoholic fatty liver disease by modulating glucose and fatty acid metabolic enzymes in a rat model.
Non-alcoholic fatty liver disease (NAFLD) is an increasingly common condition which is associated with certain features of… 
2009
2009
Preterm and infection-driven preterm labor: the role of peroxisome proliferator-activated receptors and retinoid X receptor.
Approximately 8% of births are complicated by preterm delivery. To improve neonatal outcomes, a greater understanding of the… 
2009
2009
From Molecular Shape to Potent Bioactive Agents II: Fragment‐Based de novo Design
Agonists of peroxisome proliferator-activated receptors (PPARs) are important drugs for dyslipidemia and type-II-diabetes… 
2008
2008
Determinants of plasma apolipoprotein A‐V and APOA5 gene transcripts in humans
Objective.  Apolipoprotein A‐V (apoAV) contributes to the regulation of triglyceride metabolism, which plays a role in the… 
2008
2008
Genetic testing is ready to change the diagnostic scenario of lactose malabsorption.
We write in response to the article by Swallow ( Gut 2006; 55 :131) in which a DNA test was considered premature for diagnosing… 
2007
2007
A Widely Used Retinoic Acid Receptor Antagonist Induces Peroxisome Proliferator-Activated Receptor-γ Activity
Nuclear receptors (NRs) are transcription factors whose activity is regulated by the binding of small lipophilic ligands… 
2007
2007
Uncoupling Protein-2 Up-regulation and Enhanced Cyanide Toxicity are Mediated by PPARα Activation and Oxidative Stress
2007
2007
Synergistic effect between polymorphisms of PPARA and ABCA1 genes on the premature coronary artery disease
Objective — Progression of atherosclerosis, the main reason of cardiovascular diseases, depends on multiple genetic and… 
Highly Cited
2004
Highly Cited
2004
Effects of PPARalpha, gamma and delta haplotypes on plasma levels of lipids, severity and progression of coronary atherosclerosis and response to statin therapy in the lipoprotein coronary…
Peroxisome proliferator-activated receptors (PPARs) alpha, delta and gamma are nuclear transcription factors that regulate fatty… 
1995
1995
Modulation of thyroid hormone action by mutant thyroid hormone receptors, c-erbAα2 and peroxisome proliferator-activated receptor: evidence for different mechanisms of inhibition
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