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POU2F1 gene

Known as: POU2F1, POU Domain, Class 2, Transcription Factor 1 Gene, OCT1 
This gene plays a role in transcriptional activation and modulates immunoglobulin activity.
National Institutes of Health

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Related topics

9 relations
Cell Differentiation processHomo sapiensImmune responsePOU2F1 protein, human

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POU2F1 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2017
Review
2017
Systems biology of lens development: A paradigm for disease gene discovery in the eye.
Highly Cited
2015
Highly Cited
2015
ACK1 promotes gastric cancer epithelial–mesenchymal transition and metastasis through AKT–POU2F1–ECD signalling
Amplification of the activated Cdc42‐associated kinase 1 (ACK1) gene is frequent in gastric cancer (GC). However, little is known… 
2013
2013
A common novel splice variant of SLC22A1 (OCT1) is associated with impaired responses to imatinib in patients with chronic myeloid leukaemia
Approximately one‐third of patients with chronic myeloid leukaemia will fail to achieve or maintain responses to imatinib… 
Highly Cited
2012
Highly Cited
2012
Transcription Factor Oct1 Is a Somatic and Cancer Stem Cell Determinant
Defining master transcription factors governing somatic and cancer stem cell identity is an important goal. Here we show that the… 
2011
2011
Combinatorial binding of transcription factors in the pluripotency control regions of the genome.
The pluripotency control regions (PluCRs) are defined as genomic regions that are bound by POU5F1, SOX2, and NANOG in vivo. We… 
2010
2010
Role of Organic Cation Transporter 1, OCT1 in the Pharmacokinetics and Toxicity of cis-Diammine(pyridine)chloroplatinum(II) and Oxaliplatin in Mice
ABSTRACTPurposeThe goal of this study was to test the hypothesis that by controlling intracellular uptake, organic cation… 
2010
2010
Calcium kidney stones are associated with a haplotype of the calcium-sensing receptor gene regulatory region.
BACKGROUND Calcium-sensing receptor gene (CaSR) is a candidate to explain susceptibility to calcium kidney stones. Thus, we… 
Highly Cited
2009
Highly Cited
2009
Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver
An important function of hepatocytes is the biotransformation and elimination of various drugs, many of which are organic cations… 
2008
2008
Mechanisms of SHP‐1 P2 promoter regulation in hematopoietic cells and its silencing in HTLV‐1‐transformed T cells
The Src homology‐2‐containing protein‐tyrosine phosphatase 1 (SHP‐1), is a negative regulator of cell signaling. It is also… 
Highly Cited
1990
Highly Cited
1990
Activation of octamer-containing promoters by either octamer-binding transcription factor 1 (OTF-1) or OTF-2 and requirement of an additional B-cell-specific component for optimal transcription of…
Several distinct octamer-binding transcription factors (OTFs) interact with the sequence ATTTGCAT (the octamer motif), which acts… 
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