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POLH wt Allele

Known as: XP-V, FLJ16395, RAD30A 
Human POLH wild-type allele is located in the vicinity of 6p21.1 and is approximately 44 kb in length. This allele, which encodes DNA polymerase eta… 
National Institutes of Health

Related topics

Related topics

5 relations
6p21.1DNA RepairXeroderma pigmentosum, variant type

Broader (1)

POLH gene

Narrower (1)

Rad30 protein

Papers overview

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Highly Cited
2007
Highly Cited
2007
Polymerase eta is a short-lived, proteasomally degraded protein that is temporarily stabilized following UV irradiation in Saccharomyces cerevisiae.
2007
2007
Mutator alleles of yeast DNA polymerase zeta.
The yeast REV3 gene encodes the catalytic subunit of DNA polymerase zeta (pol zeta), a B family polymerase that performs… 
2006
2006
Mgs1 and Rad18/Rad5/Mms2 are required for survival of Saccharomyces cerevisiae mutants with novel temperature/cold sensitive alleles of the DNA polymerase delta subunit, Pol31.
2006
2006
The Saccharomyces cerevisiae rev6-1 Mutation, Which Inhibits Both the Lesion Bypass and the Recombination Mode of DNA Damage Tolerance, Is an Allele of POL30, Encoding Proliferating Cell Nuclear…
The rev6-1 allele was isolated in a screen for mutants deficient for UV-induced reversion of the frameshift mutation his4-38… 
2003
2003
The link between 20S proteasome activity and post‐replication DNA repair in Saccharomyces cerevisiae
We have shown previously that deletion of the Saccharomyces cerevisiae UMP1 gene encoding the 20S proteasome maturase causes… 
Highly Cited
2001
Highly Cited
2001
Acidic Residues Critical for the Activity and Biological Function of Yeast DNA Polymerase η
ABSTRACT Rad30 is a member of the newly discovered UmuC/DinB/Rad30 family of DNA polymerases. The N-terminal regions of these… 
Review
2001
Review
2001
DNA polymerase iota and related rad30-like enzymes.
Until recently, the molecular mechanisms of translesion DNA synthesis (TLS), a process whereby a damaged base is used as a… 
Highly Cited
2000
Highly Cited
2000
Complementation of defective translesion synthesis and UV light sensitivity in xeroderma pigmentosum variant cells by human and mouse DNA polymerase
Defects in the human gene XPV result in the variant form of the genetic disease xeroderma pigmentosum (XP-V). XPV encodes DNA… 
Highly Cited
1999
Highly Cited
1999
Requirement of DNA Polymerase Activity of Yeast Rad30 Protein for Its Biological Function*
The RAD30 gene of Saccharomyces cerevisiae encodes a DNA polymerase, Polη. The Rad30 protein shares homology with the yeast Rev1… 
Highly Cited
1998
Highly Cited
1998
Deletion of the Saccharomyces cerevisiae gene RAD30 encoding an Escherichia coli DinB homolog confers UV radiation sensitivity and altered mutability
Abstract The dinB gene of Escherichia coli is an SOS-inducible gene of unknown function. Its mode of regulation and the amino… 
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