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POLA1 gene

Known as: polymerase (DNA) alpha 1, catalytic subunit, POLA DNA POLYMERASE-ALPHA, p180 SUBUNIT, POLYMERASE, DNA, ALPHA-1 
 
National Institutes of Health

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Related topics

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DNA Polymerase I

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
DNA polymerase-α regulates type I interferon activation through cytosolic RNA:DNA synthesis
Aberrant nucleic acids generated during viral replication are the main trigger for antiviral immunity, and mutations that disrupt… Expand
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Highly Cited
2014
Highly Cited
2014
Characterization of GABAB-receptor mediated neurotransmission in the human cortex by paired-pulse TMS–EEG
GABAB-receptor (GABABR) mediated inhibition is important in regulating neuronal excitability. The paired-pulse transcranial… Expand
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Highly Cited
2007
Highly Cited
2007
p180 is involved in the interaction between the endoplasmic reticulum and microtubules through a novel microtubule-binding and bundling domain.
p180 was originally reported as a ribosome-binding protein on the rough endoplasmic reticulum membrane, although its precise role… Expand
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2006
2006
Treatment with MDMA from P11–20 disrupts spatial learning and path integration learning in adolescent rats but only spatial learning in older rats
RationalePrevious studies in rats showed that postnatal day (P)11–20 exposure to ±3,4-methylenedioxymethamphetamine (MDMA… Expand
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Highly Cited
1994
Highly Cited
1994
Binding of ribosomes to the rough endoplasmic reticulum mediated by the Sec61p-complex
The cotranslational translocation of proteins across the ER membrane involves the tight binding of translating ribosomes to the… Expand
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Highly Cited
1994
Highly Cited
1994
Growth state- and cell cycle-dependent fluctuation in the expression of two forms of DNA topoisomerase II and possible specific modification of the higher molecular weight form in the M phase.
The fluctuations in the expression of two forms of DNA topoisomerase II, p170 and p180, were examined by immunoblotting during… Expand
Highly Cited
1989
Highly Cited
1989
Biochemical and pharmacological properties of p170 and p180 forms of topoisomerase II.
The p170 and p180 forms of topoisomerase II have been compared. The concentration dependence of ATP for catalytic activity of the… Expand
Highly Cited
1988
Highly Cited
1988
Mechanisms of multidrug resistance in HL60 cells: evidence that a surface membrane protein distinct from P-glycoprotein contributes to reduced cellular accumulation of drug.
HL60 cells exhibiting a 140-fold increase in resistance to vincristine contain three surface membrane proteins with molecular… Expand
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Highly Cited
1975
Highly Cited
1975
Enzymatic induction of DNA double-strand breaks in gamma-irradiated Escherichia coli K-12.
The polA1 mutation increases the sensitivity of E. coli K-12 by killing by gamma-irradiation in air by a factor of 2.9 and… Expand
Highly Cited
1972
Highly Cited
1972
Role of DNA polymerase I and the rec system in excision-repair in Escherichia coli.
The DNA polymerase I-deficient mutant polA1 is shown to perform an increased amount of UV-stimulated repair synthesis relative to… Expand
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