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PND 1186

Known as: VS-4718, PND-1186, FAK Inhibitor VS-4718 
An orally bioavailable focal adhesion kinase (FAK) inhibitor with potential antineoplastic activity. Upon administration, VS-4718 inhibits FAK… Expand
National Institutes of Health

Papers overview

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2018
2018
Overexpression of ATP-binding cassette (ABC) transporters is one of the most important mechanisms responsible for multi-drug… Expand
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2017
2017
Cancer stem cells (CSCs) play an important role in the clonogenic growth and metastasis of pancreatic ductal adenocarcinoma (PDAC… Expand
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Highly Cited
2016
Highly Cited
2016
Single-agent immunotherapy has achieved limited clinical benefit to date in patients with pancreatic ductal adenocarcinoma (PDAC… Expand
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2016
2016
BCR-ABL1+ B progenitor acute lymphoblastic leukemia (Ph+ B-ALL) is an aggressive disease that frequently responds poorly to… Expand
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Highly Cited
2015
Highly Cited
2015
Summary Focal adhesion kinase (FAK) promotes anti-tumor immune evasion. Specifically, the kinase activity of nuclear-targeted FAK… Expand
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Highly Cited
2014
Highly Cited
2014
FAK inhibitor treatment is effective against Merlin-negative mesothelioma tumors and preferentially targets cancer stem cells… Expand
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2014
2014
Proline-rich tyrosine kinase 2 (Pyk2) is a member of the focal adhesion kinase family that has been recently linked to tumor… Expand
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Highly Cited
2010
Highly Cited
2010
Tumor cells can grow in an anchorage-independent manner. This is mediated in part through survival signals that bypass normal… Expand
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Highly Cited
2010
Highly Cited
2010
Tumor metastasis is a leading cause of cancer-related death. Focal adhesion kinase (FAK) is a cytoplasmic tyrosine kinase… Expand
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1991
1991
  • Schinn, Dai, Gallagher
  • Physical review. A, Atomic, molecular, and…
  • 1991
  • Corpus ID: 35941757
The Mg 3{ital pns} ({ital n}=10--18) and 3{ital pnd} ({ital n}=9--40) doubly excited {ital J}=1 autoionizing states have been… Expand
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