Skip to search formSkip to main contentSkip to account menu

PND 1186

Known as: VS-4718, PND-1186, FAK Inhibitor VS-4718 
An orally bioavailable focal adhesion kinase (FAK) inhibitor with potential antineoplastic activity. Upon administration, VS-4718 inhibits FAK… 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (1)

Aminopyridines
NCIt Antineoplastic Agent TerminologyReceptor Tyrosine Kinase Inhibition

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Inhibition of FAK kinase activity preferentially targets cancer stem cells
Because cancer stem cells (CSCs) have been implicated in chemo-resistance, metastasis and tumor recurrence, therapeutic targeting… 
2016
2016
Abstract 3812: FAK inhibition resensitizes platinum-resistant serous ovarian cancer
Platinum and taxol administration is standard of care chemotherapy for serous ovarian cancer. Tumor recurrence occurs in a high… 
2015
2015
Abstract 1525: FAK and PI3K/mTOR inhibitors target cancer stem cells: Implications for SCLC treatment strategies
Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA Small cell lung cancer (SCLC) is an extremely… 
2015
2015
FAK/PYK2 inhibitors defactinib and VS-4718 enhance immune checkpoint inhibitor efficacy
Although durable responses to single agent immune checkpoint inhibitors have been reported, additional approaches are needed to… 
2013
2013
Focal adhesion kinase (FAK) inhibitors VS-6063 and VS-4718 target cancer stem cells.
e13523 Background: Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that orchestrates cellular signaling through… 
2013
2013
Abstract P2-09-14: Focal adhesion kinase (FAK) inhibitors VS-6063 and VS-4718 target breast cancer stem cells
Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that orchestrates cellular signaling through integrins and growth… 
2012
2012
400 FAK Inhibitor VS-4718 Attenuates Breast Cancer Stem Cell Function and Inhibits Tumor Growth in Vivo
2010
2010
PND-1186 FAK inhibitor selectively promotes tumore cell apoptosis in three-dimensional environments
Commentary to: PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments Isabelle… 
1993
1993
The sensitivity to 3,3′-iminodipropionitrile differs for high-and midfrequency hearing loss in the developing rat
1991
1991
Mg 3pns and 3pnd (J=1) autoionizing series.
The Mg 3{ital pns} ({ital n}=10--18) and 3{ital pnd} ({ital n}=9--40) doubly excited {ital J}=1 autoionizing states have been… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)