PND 1186

Known as: VS-4718, PND-1186, FAK Inhibitor VS-4718 
An orally bioavailable focal adhesion kinase (FAK) inhibitor with potential antineoplastic activity. Upon administration, VS-4718 inhibits FAK… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2010-2016
02420102016

Papers overview

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2017
2017
Cancer stem cells (CSCs) play an important role in the clonogenic growth and metastasis of pancreatic ductal adenocarcinoma (PDAC… (More)
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2016
2016
Single-agent immunotherapy has achieved limited clinical benefit to date in patients with pancreatic ductal adenocarcinoma (PDAC… (More)
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2016
2016
BCR-ABL1+ B progenitor acute lymphoblastic leukemia (Ph+ B-ALL) is an aggressive disease that frequently responds poorly to… (More)
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2015
2015
Focal adhesion kinase (FAK) promotes anti-tumor immune evasion. Specifically, the kinase activity of nuclear-targeted FAK in… (More)
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2015
2015
Although durable responses to single agent immune checkpoint inhibitors have been reported, additional approaches are needed to… (More)
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2014
2014
The goal of targeted therapy is to match a selective drug with a genetic lesion that predicts for drug sensitivity. In a diverse… (More)
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2014
2014
Ovarian cancer ascites fluid contains matrix proteins that can impact tumor growth via integrin receptor binding. In human… (More)
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2014
2014
Proline-rich tyrosine kinase 2 (Pyk2) is a member of the focal adhesion kinase family that has been recently linked to tumor… (More)
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2010
2010
Tumor cells can grow in an anchorage-independent manner. This is mediated in part through survival signals that bypass normal… (More)
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2010
2010
Tumor metastasis is a leading cause of cancer-related death. Focal adhesion kinase (FAK) is a cytoplasmic tyrosine kinase… (More)
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