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PN 401

Known as: PN-401, PN401 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (2)

Uridineuridine triacetate
analogs & derivativesfluorouracil/leucovorin calcium/methotrexate/PALA/triacetyluridine

Papers overview

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2013
2013
Uridine prodrug improves memory in Tg2576 and TAPP mice and reduces pathological factors associated with Alzheimer's disease in related models.
Uridine prodrug PN401 has been shown to have neuroprotective effects in models of Parkinson's disease and Huntington's disease… 
2006
2006
Oral uridine pro-drug PN401 is neuroprotective in the R6/2 and N171-82Q mouse models of Huntington's disease
2006
2006
5-Fluorouracil dose escalation enabled with PN401 (triacetyluridine): toxicity reduction and increased antitumor activity in mice
Purpose: PN401, an oral prodrug of uridine yields more bioavailable uridine than oral administration of uridine itself. PN401 may… 
2006
2006
Phase II trial of PN401, 5-FU, and leucovorin in unresectable or metastatic adenocarcinoma of the stomach: A Southwest Oncology Group study
SummaryFrom February, 2001 to September, 2002, the Southwest Oncology Group (SWOG) accrued 65 patients with advanced gastric… 
2005
2005
Severe cytochrome c oxidase inhibition in vivo does not induce a pyrimidine deficiency; neuroprotective action of oral uridine prodrug PN401 requires supraphysiological levels of uridine
Highly Cited
2003
Highly Cited
2003
Oral uridine pro-drug PN401 decreases neurodegeneration, behavioral impairment, weight loss and mortality in the 3-nitropropionic acid mitochondrial toxin model of Huntington's disease
2000
2000
Phase I and pharmacologic study of PN401 and fluorouracil in patients with advanced solid malignancies.
PURPOSE To assess the feasibility of administering PN401, an oral uridine prodrug, as a rescue agent for the toxic effects of… 
1997
1997
Phase I trial of PN401, an oral prodrug of uridine, to prevent toxicity from fluorouracil in patients with advanced cancer.
PURPOSE We performed a phase I study to determine the appropriate dose of PN401, a uridine (URD) prodrug, to use as a rescue… 
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