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PML wt Allele

Known as: PML, TRIM19, MYL 
Human PML wild-type allele is located in the vicinity of 15q22 and is approximately 53 kb in length. This allele, which encodes probable… Expand
National Institutes of Health

Papers overview

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2010
2010
The Bcr-Abl and Lyn protein tyrosine kinases have been separately linked to the emergence of imatinib resistance in patients with… Expand
Review
2008
Review
2008
The promyelocytic leukemia protein (PML) is a tumor suppressor identified in acute PML and implicated in the pathogenesis of a… Expand
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Review
2004
Review
2004
Promyelocytic leukaemia nuclear bodies (PML NBs) are generally present in all mammalian cells, and their integrity correlates… Expand
Highly Cited
1998
Highly Cited
1998
The PML gene of acute promyelocytic leukaemia (APL) encodes a cell growth and tumour suppressor, however, the mechanisms by which… Expand
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Highly Cited
1998
Highly Cited
1998
Inorganic arsenic trioxide (As 2 O 3 ) and the organic arsenical, melarsoprol, were recently shown to inhibit growth and induce… Expand
Highly Cited
1998
Highly Cited
1998
ABSTRACT PML is a nuclear protein with growth-suppressive properties originally identified in the context of the PML-retinoic… Expand
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Highly Cited
1998
Highly Cited
1998
The PML gene product is associated with a defined nuclear structure (10-20 per cell) known variously as PML-bodies, ND10, PODs or… Expand
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Highly Cited
1996
Highly Cited
1996
In the MYL mutant of the Arc repressor dimer, sets of partially buried salt-bridge and hydrogen-bond interactions mediated by Arg… Expand
Highly Cited
1995
Highly Cited
1995
The PML protein was first identified as part of a fusion product with the retinoic acid receptor alpha (RAR alpha), resulting… Expand
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Highly Cited
1992
Highly Cited
1992
Acute promyelocytic leukemia (APL) is due to a chromosomal t(15;17) translocation which involves a novel human gene, Myl, (also… Expand