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PML wt Allele

Known as: PML, TRIM19, MYL 
Human PML wild-type allele is located in the vicinity of 15q22 and is approximately 53 kb in length. This allele, which encodes probable… Expand
National Institutes of Health

Related topics

Related topics

11 relations
15q22Homo sapiensPML geneProbable Transcription Factor PML
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
Multicolor monitoring of dysregulated protein kinases in chronic myelogenous leukemia.
The Bcr-Abl and Lyn protein tyrosine kinases have been separately linked to the emergence of imatinib resistance in patients with… Expand
Review
2008
Review
2008
Regulation of apoptosis by PML and the PML-NBs
The promyelocytic leukemia protein (PML) is a tumor suppressor identified in acute PML and implicated in the pathogenesis of a… Expand
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Review
2004
Review
2004
PML nuclear bodies: dynamic sensors of DNA damage and cellular stress
Promyelocytic leukaemia nuclear bodies (PML NBs) are generally present in all mammalian cells, and their integrity correlates… Expand
Highly Cited
1998
Highly Cited
1998
Pml is essential for multiple apoptotic pathways
The PML gene of acute promyelocytic leukaemia (APL) encodes a cell growth and tumour suppressor, however, the mechanisms by which… Expand
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Highly Cited
1998
Highly Cited
1998
Arsenic Trioxide and Melarsoprol Induce Programmed Cell Death in Myeloid Leukemia Cell Lines and Function in a PML and PML-RAR Independent Manner
Inorganic arsenic trioxide (As 2 O 3 ) and the organic arsenical, melarsoprol, were recently shown to inhibit growth and induce… Expand
Highly Cited
1998
Highly Cited
1998
The Promyelocytic Leukemia Gene Product (PML) Forms Stable Complexes with the Retinoblastoma Protein
ABSTRACT PML is a nuclear protein with growth-suppressive properties originally identified in the context of the PML-retinoic… Expand
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Highly Cited
1998
Highly Cited
1998
Disruption of PML-associated nuclear bodies mediated by the human cytomegalovirus major immediate early gene product.
The PML gene product is associated with a defined nuclear structure (10-20 per cell) known variously as PML-bodies, ND10, PODs or… Expand
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Highly Cited
1996
Highly Cited
1996
Barriers to protein folding: formation of buried polar interactions is a slow step in acquisition of structure.
In the MYL mutant of the Arc repressor dimer, sets of partially buried salt-bridge and hydrogen-bond interactions mediated by Arg… Expand
Highly Cited
1995
Highly Cited
1995
Targeting of adenovirus E1A and E4-ORF3 proteins to nuclear matrix- associated PML bodies
The PML protein was first identified as part of a fusion product with the retinoic acid receptor alpha (RAR alpha), resulting… Expand
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Highly Cited
1992
Highly Cited
1992
Structure, localization and transcriptional properties of two classes of retinoic acid receptor alpha fusion proteins in acute promyelocytic leukemia (APL): structural similarities with a new family…
Acute promyelocytic leukemia (APL) is due to a chromosomal t(15;17) translocation which involves a novel human gene, Myl, (also… Expand
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