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PML wt Allele

Known as: PML, TRIM19, MYL 
Human PML wild-type allele is located in the vicinity of 15q22 and is approximately 53 kb in length. This allele, which encodes probable… Expand
National Institutes of Health

Related topics

Related topics

11 relations
15q22Homo sapiensPML geneProbable Transcription Factor PML
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Papers overview

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Highly Cited
2009
Highly Cited
2009
Cell death induced by dexamethasone in lymphoid leukemia is mediated through initiation of autophagy
 
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Review
2008
Review
2008
Regulation of apoptosis by PML and the PML-NBs
The promyelocytic leukemia protein (PML) is a tumor suppressor identified in acute PML and implicated in the pathogenesis of a… Expand
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Review
2004
Review
2004
PML nuclear bodies: dynamic sensors of DNA damage and cellular stress.
Promyelocytic leukaemia nuclear bodies (PML NBs) are generally present in all mammalian cells, and their integrity correlates… Expand
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Highly Cited
2000
Highly Cited
2000
Disruption of PML-associated nuclear bodies by IE1 correlates with efficient early stages of viral gene expression and DNA replication in human cytomegalovirus infection.
In human cytomegalovirus (HCMV) infection, both of the major immediate-early proteins IE1(IE68, UL123) and IE2(IE86, UL122… Expand
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Highly Cited
1998
Highly Cited
1998
Pml is essential for multiple apoptotic pathways
The PML gene of acute promyelocytic leukaemia (APL) encodes a cell growth and tumour suppressor, however, the mechanisms by which… Expand
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Highly Cited
1998
Highly Cited
1998
Disruption of PML-associated nuclear bodies mediated by the human cytomegalovirus major immediate early gene product.
The PML gene product is associated with a defined nuclear structure (10-20 per cell) known variously as PML-bodies, ND10, PODs or… Expand
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Highly Cited
1998
Highly Cited
1998
The promyelocytic leukemia gene product (PML) forms stable complexes with the retinoblastoma protein.
PML is a nuclear protein with growth-suppressive properties originally identified in the context of the PML-retinoic acid… Expand
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Highly Cited
1998
Highly Cited
1998
Arsenic trioxide and melarsoprol induce programmed cell death in myeloid leukemia cell lines and function in a PML and PML-RARalpha independent manner.
Inorganic arsenic trioxide (As2O3) and the organic arsenical, melarsoprol, were recently shown to inhibit growth and induce… Expand
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Highly Cited
1995
Highly Cited
1995
Targeting of adenovirus E1A and E4-ORF3 proteins to nuclear matrix- associated PML bodies
The PML protein was first identified as part of a fusion product with the retinoic acid receptor alpha (RAR alpha), resulting… Expand
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Highly Cited
1992
Highly Cited
1992
Structure, localization and transcriptional properties of two classes of retinoic acid receptor alpha fusion proteins in acute promyelocytic leukemia (APL): structural similarities with a new family…
Acute promyelocytic leukemia (APL) is due to a chromosomal t(15;17) translocation which involves a novel human gene, Myl, (also… Expand
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