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PMEL gene

Known as: SILV, Silver Homolog (Mouse) Gene, PMEL 
This gene plays a role in melanosome biogenesis. It is also involved in T-cell recognition.
National Institutes of Health

Related topics

Related topics

5 relations
Immune responseMelanogenesisSILV protein, humangp100 Antigen

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SILV wt Allele

Papers overview

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Highly Cited
2009
Highly Cited
2009
Design of agonistic altered peptides for the robust induction of CTL directed towards H-2Db in complex with the melanoma-associated epitope gp100.
Immunogenicity of tumor-associated antigens (TAA) is often weak because many TAA are autoantigens for which the T-cell repertoire… 
Highly Cited
2003
Highly Cited
2003
Targeted immunotherapy using reconstituted chaperone complexes of heat shock protein 110 and melanoma-associated antigen gp100.
This report defines a novel approach to heat shock protein vaccine formulation that takes advantage of the chaperoning property… 
Highly Cited
2002
Highly Cited
2002
Multiple HLA Class II-Restricted Melanocyte Differentiation Antigens Are Recognized by Tumor-Infiltrating Lymphocytes from a Patient with Melanoma
Dramatic clinical responses were observed in patient 888 following the adoptive transfer of autologous tumor-infiltrating… 
Highly Cited
2001
Highly Cited
2001
Comprehensive analysis of the frequency of recognition of melanoma‐associated antigen (MAA) by CD8 melanoma infiltrating lymphocytes (TIL): implications for immunotherapy
Fifty‐nine tumor‐infiltrating lymphocyte (TIL) cultures established from melanoma‐invaded lymph nodes were screened for… 
Highly Cited
2001
Highly Cited
2001
Therapeutic tumor immunity induced by polyimmunization with melanoma antigens gp100 and TRP-2.
To improve the immunogenicity of melanoma self-antigens, we used a novel strategy of nonviral genetic vaccination coupled with… 
Highly Cited
2000
Highly Cited
2000
Detailed characterization of anodic bonding process between glass and thin-film coated silicon substrates
Highly Cited
2000
Highly Cited
2000
Effects of distraction on pain-related somatosensory evoked magnetic fields and potentials following painful electrical stimulation.
Highly Cited
2000
Highly Cited
2000
Sustained activation of p42/p44 mitogen-activated protein kinase during recovery from simulated ischaemia mediates adaptive cytoprotection in cardiomyocytes.
Delayed cytoprotection (preconditioning) occurs 24 h after sublethal simulated ischaemia and reperfusion (SI/R) in neonatal rat… 
Highly Cited
2000
Highly Cited
2000
Characteristics of the human contra- versus ipsilateral SII cortex
Highly Cited
1995
Highly Cited
1995
Regional Specialization of Intraepithelial T Cells in the Murine Small and Large Intestine
We investigated intraepithelial T cells from the small intestine, SI (jejunum, ileum) and the large intestine, LI (colon) of… 
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