Design of agonistic altered peptides for the robust induction of CTL directed towards H-2Db in complex with the melanoma-associated epitope gp100.

@article{Stipdonk2009DesignOA,
  title={Design of agonistic altered peptides for the robust induction of CTL directed towards H-2Db in complex with the melanoma-associated epitope gp100.},
  author={Marianne J B van Stipdonk and Daniel Badia-Martinez and Marjolein Sluijter and Rienk Offringa and Thorbald van Hall and Adnane Achour},
  journal={Cancer research},
  year={2009},
  volume={69 19},
  pages={7784-92}
}
Immunogenicity of tumor-associated antigens (TAA) is often weak because many TAA are autoantigens for which the T-cell repertoire is sculpted by tolerance mechanisms. Substitutions at main anchor positions to increase the complementarity between the peptide and the MHC class I (MHC-I) binding cleft constitute a common procedure to improve binding capacity and immunogenicity of TAA. However, such alterations are tailored for each MHC-I allele and may recruit different CTL specificities through… CONTINUE READING