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PLCG2 wt Allele

Known as: PLCgamma2, Phospholipase C, Gamma 2 (Phosphatidylinositol-Specific) wt Allele, Phospholipase C, Phosphatidylinositol-Specific Gene 
Human PLCG2 wild-type allele is located within the vicinity of 16q24.1 and is approximately 179 kb in length. This allele, which encodes 1… 
National Institutes of Health

Related topics

Related topics

10 relations
16q24.1B Cell Receptor Signaling PathwayERBB Family Signaling PathwayErythropoietin Signaling Pathway

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Functional characterization of phospholipase C-γ2 mutant protein causing both somatic ibrutinib resistance and a germline monogenic autoinflammatory disorder
Depending on its occurrence in the germline or somatic context, a single point mutation, S707Y, of phospholipase C-γ2 (PLCγ2… 
Review
2010
Review
2010
PLCγ2: where bone and immune cells find their common ground
Identifying common signaling pathways to bone and immune system may lead to better therapeutic approaches in diseases such as… 
2008
2008
Evaluation of the physiological significance of botrocetin/ von Willebrand factor in vitro signaling
Summary.  Background: A signaling pathway is difficult, if not impossible, to elucidate in platelets using only in vivo studies… 
2007
2007
Phospholipase Cγ2 Contributes to Light-Chain Gene Activation and Receptor Editing
ABSTRACT Phospholipase Cγ2 (PLCγ2) is critical for pre-B-cell receptor (pre-BCR) and BCR signaling. Current studies discovered… 
2007
2007
Btk and phospholipase C gamma 2 can function independently during B cell development.
The pre-BCR and the BCR regulate B cell development via a signalosome nucleated by the adaptor protein B cell linker protein… 
2006
2006
A new role for FcgammaRIIA in the potentiation of human platelet activation induced by weak stimulation.
The low affinity receptor for immunoglobulin G, FcgammaRIIA, is expressed in human platelets, mediates heparin-induced… 
2006
2006
Distinct Roles of Phosphoinositide-3 Kinase and Phospholipase Cγ2 in B-Cell Receptor-Mediated Signal Transduction
ABSTRACT During B-cell receptor (BCR) signaling, phosphoinositide-3 kinase (PI3K) is thought to function upstream of… 
2004
2004
PLCγ2 regulates Bcl‐2 levels and is required for survival rather than differentiation of marginal zone and follicular B cells
B cells from phospholipase C (PLC)γ2‐deficient mice express reduced levels of the pro‐survival protein Bcl‐2 and show a defect in… 
Highly Cited
2001
Highly Cited
2001
Vav1 Regulates Phospholipase Cγ Activation and Calcium Responses in Mast Cells
ABSTRACT The hematopoietic cell-specific protein Vav1 is a substrate of tyrosine kinases activated following engagement of many… 
1999
1999
Signal transduction pathways mediated by glycoprotein Ia/IIa in human platelets: comparison with those of glycoprotein VI.
Human platelets were activated either by glycoprotein (GP) Ia/IIa agonist (rhodocytin) or by a GPVI agonist (collagen-related… 
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