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PITX2 gene

Known as: Otlx2, RS, paired like homeodomain 2 
This gene is involved in both the development of the pancreas and transcriptional regulation.
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
Summary Background Various genome-wide association studies (GWAS) have been done in ischaemic stroke, identifying a few loci… Expand
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Highly Cited
2010
Highly Cited
2010
Atrial fibrillation (AF), the most prevalent sustained cardiac arrhythmia, often coexists with the related arrhythmia atrial… Expand
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Highly Cited
2003
Highly Cited
2003
Two closely related homeobox transcription factors, Pitx1 and Pitx2, have been implicated in patterning of lateral plate mesoderm… Expand
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Highly Cited
1999
Highly Cited
1999
Pitx1 (refs 1,2,3) and Pitx2 (refs 4, 5) are highly homologous, bicoid-related transcription factors. Pitx2 was initially… Expand
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Highly Cited
1999
Highly Cited
1999
Pitx2, a bicoid-related homeobox gene, is involved in Rieger's syndrome and the left-right (L-R) asymmetrical pattern formation… Expand
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Highly Cited
1999
Highly Cited
1999
Pitx2 is a homeodomain transcription factor that is mutated in Rieger syndrome, a haploinsufficiency disorder affecting eyes and… Expand
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Highly Cited
1998
Highly Cited
1998
The handedness of visceral organs is conserved among vertebrates and is regulated by asymmetric signals relayed by molecules such… Expand
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Highly Cited
1998
Highly Cited
1998
Signaling molecules such as Activin, Sonic hedgehog, Nodal, Lefty, and Vg1 have been found to be involved in determination of… Expand
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Highly Cited
1998
Highly Cited
1998
The mechanism by which asymmetric signals induce left-right-specific morphogenesis has been elusive. Pitx2 encodes a… Expand
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Highly Cited
1996
Highly Cited
1996
Rieger syndrome (REG) is an autosomal–dominant human disorder that includes anomalies of the anterior chamber of the eye, dental… Expand
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