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PITX2 gene

Known as: Otlx2, RS, paired like homeodomain 2 
This gene is involved in both the development of the pancreas and transcriptional regulation.
National Institutes of Health

Related topics

Related topics

10 relations
Axenfeld-Rieger Syndrome, Type 1Homo sapiensIRIDOGONIODYSGENESIS, TYPE 2Organogenesis

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
Prevalence and spectrum of PITX2c mutations associated with familial atrial fibrillation.
2012
2012
PITX2: A promising predictive biomarker of patients' prognosis and chemoradioresistance in esophageal squamous cell carcinoma
The paired‐like homeodomain transcription factor 2 (PITX2), a downstream effector of wnt/β‐catenin signaling, is well known to… 
2011
2011
GABAergic and glutamatergic identities of developing midbrain Pitx2 neurons
Pitx2, a paired‐like homeodomain transcription factor, is expressed in post‐mitotic neurons within highly restricted domains of… 
Highly Cited
2008
Highly Cited
2008
Pitx2 is functionally important in the early stages of vascular smooth muscle cell differentiation
Mechanisms that control vascular smooth muscle cell (SMC) differentiation are poorly understood. We identify Pitx2 as a… 
2006
2006
Reduced human and murine corneal thickness in an Axenfeld-Rieger syndrome subtype.
PURPOSE Axenfeld-Rieger malformations of the anterior segment are clinically heterogeneous, and up to 50% of cases are… 
Highly Cited
2004
Highly Cited
2004
Molecular basis of Peters anomaly in Saudi Arabia
Peters anomaly (PA) and primary congenital glaucoma (PCG) are genetically and phenotypically distinct conditions. Mutations in… 
2004
2004
Cell-specific Activation of the Atrial Natriuretic Factor Promoter by PITX2 and MEF2A*
The PITX2 homeodomain protein is mutated in patients with Axenfeld-Rieger syndrome and is involved in the development of multiple… 
2002
2002
Genetic Analysis of PITX2 and FOXC1 in Rieger Syndrome Patients From Brazil
PurposeAxenfeld-Rieger syndrome is a genetically heterogenous, autosomal dominant disorder that is characterized by anterior… 
Highly Cited
2001
Highly Cited
2001
Antagonistic regulation of Dlx2 expression by PITX2 and Msx2: implications for tooth development.
The transcriptional mechanisms underlying tooth development are only beginning to be understood. Pitx2, a bicoid-like homeodomain… 
2001
2001
Xpitx3: a member of the Rieg/Pitx gene family expressed during pituitary and lens formation in Xenopus laevis
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