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PITX2 gene

Known as: Otlx2, RS, paired like homeodomain 2 
This gene is involved in both the development of the pancreas and transcriptional regulation.
National Institutes of Health

Related topics

Related topics

10 relations
Axenfeld-Rieger Syndrome, Type 1Homo sapiensIRIDOGONIODYSGENESIS, TYPE 2Organogenesis

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2006
Highly Cited
2006
Functional interactions between FOXC1 and PITX2 underlie the sensitivity to FOXC1 gene dose in Axenfeld-Rieger syndrome and anterior segment dysgenesis.
Axenfeld-Rieger ocular dysgenesis is associated with mutations of the human PITX2 and FOXC1 genes, which encode transcription… 
Highly Cited
2003
Highly Cited
2003
Pitx1 and Pitx2 are required for development of hindlimb buds
Two closely related homeobox transcription factors, Pitx1 and Pitx2, have been implicated in patterning of lateral plate mesoderm… 
Highly Cited
2003
Highly Cited
2003
The Wnt/beta-catenin-->Pitx2 pathway controls the turnover of Pitx2 and other unstable mRNAs.
Highly Cited
2002
Highly Cited
2002
Differential Regulation of Gene Expression by PITX2 Isoforms*
Three major PITX2 isoforms are differentially expressed in human, mice, zebrafish, chick, and frog tissues. To demonstrate… 
Highly Cited
2000
Highly Cited
2000
Mesendoderm and left-right brain, heart and gut development are differentially regulated by pitx2 isoforms.
The pitx2 gene is a member of the bicoid-homeodomain class of transcription factors that has been implicated in the control of… 
Highly Cited
2000
Highly Cited
2000
Antagonistic signals between BMP4 and FGF8 define the expression of Pitx1 and Pitx2 in mouse tooth-forming anlage.
Members of the Pitx/RIEG family of homeodomain-containing transcription factors have been implicated in vertebrate organogenesis… 
Highly Cited
1999
Highly Cited
1999
Pitx2 regulates lung asymmetry, cardiac positioning and pituitary and tooth morphogenesis
Pitx1 (refs 1,2,3) and Pitx2 (refs 4, 5) are highly homologous, bicoid-related transcription factors. Pitx2 was initially… 
Highly Cited
1999
Highly Cited
1999
Function of Rieger syndrome gene in left–right asymmetry and craniofacial development
Rieger syndrome, an autosomal dominant disorder, includes ocular, craniofacial and umbilical abnormalities. The pitx2 homeobox… 
Highly Cited
1998
Highly Cited
1998
A novel homeobox gene PITX3 is mutated in families with autosomal-dominant cataracts and ASMD
We report here the identification of a new human homeobox gene, PITX3, and its involvement in anterior segment mesenchymal… 
Highly Cited
1998
Highly Cited
1998
Pitx2, a Bicoid-Type Homeobox Gene, Is Involved in a Lefty-Signaling Pathway in Determination of Left-Right Asymmetry
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