PITX2: A promising predictive biomarker of patients' prognosis and chemoradioresistance in esophageal squamous cell carcinoma

@article{Zhang2013PITX2AP,
  title={PITX2: A promising predictive biomarker of patients' prognosis and chemoradioresistance in esophageal squamous cell carcinoma},
  author={J. Zhang and Zhu-Ting Tong and L. Yang and Fan Wang and H. Chai and F. Zhang and Mingran Xie and An-li Zhang and Li-ming Wu and Hao Hong and L. Yin and H. Wang and Yuan Zhao},
  journal={International Journal of Cancer},
  year={2013},
  volume={132}
}
  • J. Zhang, Zhu-Ting Tong, +11 authors Yuan Zhao
  • Published 2013
  • Biology, Medicine
  • International Journal of Cancer
  • The paired‐like homeodomain transcription factor 2 (PITX2), a downstream effector of wnt/β‐catenin signaling, is well known to play critical role during normal embryonic development. However, the possible involvement of PITX2 in human tumorigenesis remains unclear. In this study, we extend its function in human esophageal squamous cell carcinoma (ESCC). The real‐time PCR, Western blotting and immunohistochemistry (IHC) methods were applied to examine expression pattern of PITX2 in two different… CONTINUE READING
    23 Citations
    Downregulation of MicroRNA-644a Promotes Esophageal Squamous Cell Carcinoma Aggressiveness and Stem Cell–like Phenotype via Dysregulation of PITX2
    • 33
    • Highly Influenced
    • PDF
    Upregulation of PITX2 Promotes Letrozole Resistance Via Transcriptional Activation of IFITM1 Signaling in Breast Cancer Cells
    • Yingying Xu, H. Yu, +8 authors Q. Zhang
    • Medicine
    • Cancer research and treatment : official journal of Korean Cancer Association
    • 2019
    • 4
    • PDF
    Promising, new prognostic markers of esophageal carcinomas
    • S. Kapoor
    • Medicine, Biology
    • APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
    • 2013
    • 3

    References

    SHOWING 1-10 OF 63 REFERENCES
    The Significance of PITX2 Overexpression in Human Colorectal Cancer
    • 31
    DNA Methylation of the Homeobox Genes PITX2 and SHOX2 Predicts Outcome in Non–small-cell Lung Cancer Patients
    • 71
    FRAT1 overexpression leads to aberrant activation of β‐catenin/TCF pathway in esophageal squamous cell carcinoma
    • 33
    Multicenter study using paraffin-embedded tumor tissue testing PITX2 DNA methylation as a marker for outcome prediction in tamoxifen-treated, node-negative breast cancer patients.
    • N. Harbeck, I. Nimmrich, +17 authors R. Lesche
    • Medicine
    • Journal of clinical oncology : official journal of the American Society of Clinical Oncology
    • 2008
    • 91
    Pituitary homeobox 2 (PITX2) promotes thyroid carcinogenesis by activation of cyclin D2
    • 36