PITX2: A promising predictive biomarker of patients' prognosis and chemoradioresistance in esophageal squamous cell carcinoma

  title={PITX2: A promising predictive biomarker of patients' prognosis and chemoradioresistance in esophageal squamous cell carcinoma},
  author={J. Zhang and Zhu-Ting Tong and L. Yang and Fan Wang and H. Chai and F. Zhang and Mingran Xie and An-li Zhang and Li-ming Wu and Hao Hong and L. Yin and H. Wang and Yuan Zhao},
  journal={International Journal of Cancer},
  • J. Zhang, Zhu-Ting Tong, +11 authors Yuan Zhao
  • Published 2013
  • Biology, Medicine
  • International Journal of Cancer
  • The paired‐like homeodomain transcription factor 2 (PITX2), a downstream effector of wnt/β‐catenin signaling, is well known to play critical role during normal embryonic development. However, the possible involvement of PITX2 in human tumorigenesis remains unclear. In this study, we extend its function in human esophageal squamous cell carcinoma (ESCC). The real‐time PCR, Western blotting and immunohistochemistry (IHC) methods were applied to examine expression pattern of PITX2 in two different… CONTINUE READING
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