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PIM1 protein, human

Known as: Lon protease Pim1, human, c-pim-1 protein, human, pim-1 proto-oncogene protein, human 
Serine/threonine-protein kinase pim-1 (404 aa, ~45 kDa) is encoded by the human PIM1 gene. This protein plays a role in both cell proliferation and… 
National Institutes of Health

Related topics

Related topics

14 relations
Enzyme GeneGerm CellsHematopoiesisHematopoietic and Lymphoid Cell

Broader (2)

Protein-Serine-Threonine KinasesProto-Oncogene Proteins c-pim-1

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
PIM1 overexpression in T-cell lymphomas protects tumor cells from apoptosis and confers doxorubicin resistance by upregulating c-myc expression
T-cell lymphomas (TCLs) are a malignancy characterized by tumor aggression and resistance to traditional chemotherapy. Disruption… 
2018
2018
PIM1-catalyzed CBX8 phosphorylation promotes the oncogene-induced senescence of human diploid fibroblast.
2017
2017
PIM1 knockdown inhibits cell proliferation and invasion of mesothelioma cells.
Malignant mesothelioma is a major asbestos-related cancer with prolonged time lapse from the first exposure of asbestos to the… 
Highly Cited
2016
Highly Cited
2016
miR-542-3p suppresses invasion and metastasis by targeting the proto-oncogene serine/threonine protein kinase, PIM1, in melanoma.
2015
2015
GTP is an allosteric modulator of the interaction between the guanylate-binding protein 1 and the prosurvival kinase PIM1.
2012
2012
Loss of Pim1 Imposes a Hyperadhesive Phenotype on Endothelial Cells
Background: PIM1 is a constitutively active serine-threonine kinase regulating cell survival and proliferation. Increased PIM1… 
2012
2012
Nuclear PIM1 confers resistance to rapamycin-impaired endothelial proliferation.
2007
2007
PIM1 and MYC: a changing relationship?
PIM protein kinases have been known for some time as oncogenes that promote lymphomagenesis together with MYC (c-Myc). It is now… 
2005
2005
Structural properties of substrate proteins determine their proteolysis by the mitochondrial AAA+ protease Pim1
Abstract The protease Pim1/LON, a member of the AAA+ family of homo-oligomeric ATP-dependent proteases, is responsible for the… 
Highly Cited
1996
Highly Cited
1996
Substitution of PIM1 Protease in Mitochondria by Escherichia coli Lon Protease (*)
PIM1 protease in mitochondria belongs to a conserved family of ATP-dependent proteases, which includes the Escherichia coli Lon… 
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