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PIM1 gene

Known as: ONCOGENE PIM 1, SERINE/THREONINE PROTEIN KINASE PIM1, Pim-1 proto-oncogene, serine/threonine kinase 
This gene is involved in apoptosis, cell cycle regulation and signal transduction.
National Institutes of Health

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Related topics

6 relations
HematopoiesisPIM1 protein, humanPhosphorylationSerine/Threonine Phosphorylation

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PIM1 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Targeting PIM kinase as a therapeutic strategy in human hepatoblastoma
Increasing incidence coupled with poor prognosis and treatments that are virtually unchanged over the past 20 years have made the… 
Highly Cited
2016
Highly Cited
2016
miR-542-3p suppresses invasion and metastasis by targeting the proto-oncogene serine/threonine protein kinase, PIM1, in melanoma.
2016
2016
Targeting of glioblastoma cell lines and glioma stem cells by combined PIM kinase and PI3K-p110α inhibition
The PIM family of proteins encodes serine/threonine kinases with important roles in protein synthesis and cancer cell metabolism… 
2015
2015
The discovery and optimization of aminooxadiazoles as potent Pim kinase inhibitors.
2014
2014
Combination of PIM and JAK2 inhibitors synergistically suppresses cell proliferation and overcomes drug resistance of myeloproliferative neoplasms
Inhibitors of JAK2 kinase are emerging as an important treatment modality for myeloproliferative neoplasms (MPN). However… 
2013
2013
Tricyclic Benzo[cd]azulenes Selectively Inhibit Activities of Pim Kinases and Restrict Growth of Epstein-Barr Virus-Transformed Cells
Oncogenic Pim family kinases are often overexpressed in human hematopoietic malignancies as well as in solid tumours. These… 
2011
2011
PIM kinase isoform specific regulation of MIG6 expression and EGFR signaling in prostate cancer cells
The PIM family of oncogenic serine/threonine kinases regulates tumour cell proliferation. To identify proliferative signaling… 
Review
2010
Review
2010
Fighting tumor cell survival: advances in the design and evaluation of Pim inhibitors.
The Pim (provirus insertion site of Moloney murine leukemia virus) family of serine/threonine protein kinases possesses the… 
1999
1999
Effects of Pimobendan on the L-Type Ca2+ Current and Developed Tension in Guinea-Pig Ventricular Myocytes and Papillary Muscle: Comparison with IBMX, Milrinone, and Cilostazol
Summary. In this study, we compared the effects of pimobenda (PIM), a putative Ca2+-sensitizer and phosphodiesterase (PDE… 
1995
1995
Structure and sequence variation of the genes encoding the polymorphic, immunodominant molecule (PIM), an antigen of Theileria parva recognized by inhibitory monoclonal antibodies.
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