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PIK3R1 gene

Known as: PIK3R1, phosphoinositide-3-kinase regulatory subunit alpha, p85 
This gene is involved in phosphoinositol signaling.
National Institutes of Health

Related topics

Related topics

8 relations
Class Ia Phosphatidylinositol 3-Kinase, p85alpha SubunitPIK3R3 genePhosphatidylinositol 3-Kinase Regulatory Subunit AlphaPhosphorylation

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PIK3R1 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Deregulated Gab2 phosphorylation mediates aberrant AKT and STAT3 signaling upon PIK3R1 loss in ovarian cancer
Copy number loss of PIK3R1 (p85α) most commonly occurs in ovarian cancer among all cancer types. Here we report that ovarian… 
Highly Cited
2018
Highly Cited
2018
microRNA-155 positively regulates glucose metabolism via PIK3R1-FOXO3a-cMYC axis in breast cancer
MicroRNA is an endogenous, small RNA controlling multiple target genes and playing roles in various biological processes… 
Review
2017
Review
2017
Ginsenoside Rb1 for Myocardial Ischemia/Reperfusion Injury: Preclinical Evidence and Possible Mechanisms
Ginseng is an important herbal drug that has been used worldwide for many years. Ginsenoside Rb1 (G-Rb1), the major… 
Highly Cited
2015
Highly Cited
2015
PIK3R1 targeting by miR-21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT, and predicts clinical outcome of breast cancer
We have previously shown that dysregulation of miR-21 functioned as an oncomiR in breast cancer. The aim of the present study was… 
2014
2014
Brain distribution pharmacokinetics and integrated pharmacokinetics of Panax Notoginsenoside R1, Ginsenosides Rg1, Rb1, Re and Rd in rats after intranasal administration of Panax Notoginseng Saponins…
Highly Cited
2014
Highly Cited
2014
Ginsenoside Rb1 improves postoperative fatigue syndrome by reducing skeletal muscle oxidative stress through activation of the PI3K/Akt/Nrf2 pathway in aged rats.
Highly Cited
2013
Highly Cited
2013
Mutations in PIK3R1 cause SHORT syndrome.
2012
2012
Metabolite profiling and pharmacokinetics of herbal compounds following oral administration of a cardiovascular multi-herb medicine (Qishen yiqi pills) in rats.
Qishen yiqi pills (QY pills) are a type of standardized cardiovascular herbal medicine, which contain four component herbs, i.e… 
Highly Cited
2011
Highly Cited
2011
PIK3R1 (p85α) is somatically mutated at high frequency in primary endometrial cancer.
Phosphoinositide 3-kinase (PI3K) is an important therapeutic target. Mutations in PIK3CA, which encodes p110α, the catalytic… 
Highly Cited
2009
Highly Cited
2009
Structural and functional studies of the Ras-associating and pleckstrin-homology domains of Grb10 and Grb14
Growth factor receptor–binding proteins Grb7, Grb10 and Grb14 are adaptor proteins containing a Ras-associating (RA) domain, a… 
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