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PI103

Known as: PI 103, PI-103 
National Institutes of Health

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3 relations

Broader (3)

FuransPyridinesPyrimidines

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
PI-103 attenuates PI3K-AKT signaling and induces apoptosis in murineT-cell lymphoma
Abstract Aberrant activation of PI3K-AKT signaling in many pathological conditions including cancer has attracted much of… 
2015
2015
Role of phosphoinositide 3-kinase IA (PI3K-IA) activation in cardioprotection induced by ouabain preconditioning.
2015
2015
β-TrCP1 degradation is a novel action mechanism of PI3K/mTOR inhibitors in triple-negative breast cancer cells
An F-box protein, β-TrCP recognizes substrate proteins and destabilizes them through ubiquitin-dependent proteolysis. It… 
2015
2015
Overexpression of PI3K p110α contributes to acquired resistance to MET inhibitor, in MET-amplified SNU-5 gastric xenografts
Gastric cancer is one of the most virulent malignant diseases and is the second leading cause of cancer mortality in the world… 
2012
2012
A Yeast-Based In Vivo Bioassay to Screen for Class I Phosphatidylinositol 3-Kinase Specific Inhibitors
The phosphatidylinositol 3-kinase (PI3K) pathway couples receptor-mediated signaling to essential cellular functions by… 
2012
2012
Different PI 3-kinase inhibitors have distinct effects on endothelial permeability and leukocyte transmigration.
2011
2011
Obesity, insulin and chemoresistance in colon cancer.
Obesity, a condition characterised by chronic hyperinsulinemia, is a firmly established risk factor for incident colon cancer (1… 
Highly Cited
2009
Highly Cited
2009
Effect of ZSTK474, a novel phosphatidylinositol 3-kinase inhibitor, on DNA-dependent protein kinase.
Phosphatidylinositol 3-kinase (PI3K) has been implicated in a variety of diseases including cancer. A number of PI3K inhibitors… 
Highly Cited
2008
Highly Cited
2008
Genetic or pharmaceutical blockade of p110delta phosphoinositide 3-kinase enhances IgE production.
Highly Cited
2008
Highly Cited
2008
Dual inhibition of PI3Kalpha and mTOR as an alternative treatment for Kaposi's sarcoma.
Rapamycin (or sirolimus), the prototypical inhibitor of the mammalian target of rapamycin (mTOR) and an immunosuppressant used… 
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