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PI103

Known as: PI 103, PI-103 
National Institutes of Health

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3 relations

Broader (3)

FuransPyridinesPyrimidines

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Novel chemotherapeutic agent, FND-4b, activates AMPK and inhibits colorectal cancer cell proliferation
Colorectal cancer (CRC) is the second leading cause of cancer deaths in the US with the majority of deaths due to metastatic… 
2015
2015
Role of phosphoinositide 3-kinase IA (PI3K-IA) activation in cardioprotection induced by ouabain preconditioning.
2015
2015
Overexpression of PI3K p110α contributes to acquired resistance to MET inhibitor, in MET-amplified SNU-5 gastric xenografts
Gastric cancer is one of the most virulent malignant diseases and is the second leading cause of cancer mortality in the world… 
2013
2013
Molecular and Cellular Pathobiology FOXO 3 a Is a Major Target of Inactivation by PI 3 K / AKT Signaling in Aggressive Neuroblastoma
Neuroblastoma is a pediatric tumor of the peripheral sympathetic nervous system with a highly variable prognosis. Activation of… 
2013
2013
PI-103 sensitizes acute myeloid leukemia stem cells to daunorubicin-induced cytotoxicity
To date, acute myeloid leukemia (AML) shows very poor outcome for conventional chemotherapy. Leukemia stem cells (LSCs) are… 
2012
2012
A Yeast-Based In Vivo Bioassay to Screen for Class I Phosphatidylinositol 3-Kinase Specific Inhibitors
The phosphatidylinositol 3-kinase (PI3K) pathway couples receptor-mediated signaling to essential cellular functions by… 
2011
2011
Obesity, insulin and chemoresistance in colon cancer.
Obesity, a condition characterised by chronic hyperinsulinemia, is a firmly established risk factor for incident colon cancer (1… 
Highly Cited
2009
Highly Cited
2009
Effect of ZSTK474, a novel phosphatidylinositol 3-kinase inhibitor, on DNA-dependent protein kinase.
Phosphatidylinositol 3-kinase (PI3K) has been implicated in a variety of diseases including cancer. A number of PI3K inhibitors… 
Highly Cited
2008
Highly Cited
2008
Genetic or pharmaceutical blockade of p110delta phosphoinositide 3-kinase enhances IgE production.
Highly Cited
2008
Highly Cited
2008
Dual inhibition of PI3Kalpha and mTOR as an alternative treatment for Kaposi's sarcoma.
Rapamycin (or sirolimus), the prototypical inhibitor of the mammalian target of rapamycin (mTOR) and an immunosuppressant used… 
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