PI103

Known as: PI 103, PI-103 
 
National Institutes of Health

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Broader (3)

FuransPyridinesPyrimidines

Papers overview

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2011
2011
Troxerutin protects against high cholesterol-induced cognitive deficits in mice.
Recent findings suggest that neurotoxicity is the mechanism underlying the induction of neuronal insulin resistance by a high… (More)
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2011
2011
Targeting aberrant PI3K/Akt activation by PI103 restores sensitivity to TRAIL-induced apoptosis in neuroblastoma.
PURPOSE Because we recently identified Akt activation as a novel poor prognostic indicator in neuroblastoma, we investigated… (More)
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Highly Cited
2010
Highly Cited
2010
Chemogenomic profiling provides insights into the limited activity of irreversible EGFR Inhibitors in tumor cells expressing the T790M EGFR resistance mutation.
Reversible epidermal growth factor receptor (EGFR) inhibitors are the first class of small molecules to improve progression-free… (More)
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Review
2010
Review
2010
The tumor microenvironment in non-small-cell lung cancer.
The tumor microenvironment (TME) of NSCLC is heterogeneous with variable blood flow through leaky immature vessels resulting in… (More)
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Highly Cited
2010
Highly Cited
2010
PI-103 and sorafenib inhibit hepatocellular carcinoma cell proliferation by blocking Ras/Raf/MAPK and PI3K/AKT/mTOR pathways.
BACKGROUND Aberrant Ras/Raf/MAPK and PI3K/AKT/mTOR signaling pathways are found in hepatocellular carcinoma (HCC). This study… (More)
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2010
2010
Oncostatin M-enhanced vascular endothelial growth factor expression in human vascular smooth muscle cells involves PI3K-, p38 MAPK-, Erk1/2- and STAT1/STAT3-dependent pathways and is attenuated by…
The pleiotropic cytokine oncostatin M (OSM), a member of the glycoprotein (gp)130 ligand family, plays a key role in inflammation… (More)
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2008
2008
Chemical genetic analysis of FOXO nuclear-cytoplasmic shuttling by using image-based cell screening.
FOXO proteins are direct targets of PI3K/Akt signaling and they integrate the signals of several other transduction pathways at… (More)
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2008
2008
Genetic or pharmaceutical blockade of p110delta phosphoinositide 3-kinase enhances IgE production.
BACKGROUND Recent studies indicate that pharmaceutical blockade of phosphoinositide 3-kinase (PI3K) signaling enzymes might be… (More)
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Highly Cited
2007
Highly Cited
2007
Pharmacologic characterization of a potent inhibitor of class I phosphatidylinositide 3-kinases.
Extensive evidence implicates activation of the lipid phosphatidylinositide 3-kinase (PI3K) pathway in the genesis and… (More)
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Highly Cited
2006
Highly Cited
2006
A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma.
The PI3 kinase family of lipid kinases promotes cell growth and survival by generating the second messenger phosphatidylinositol… (More)
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