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PI103

Known as: PI 103, PI-103 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (3)

FuransPyridinesPyrimidines

Papers overview

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Highly Cited
2016
Highly Cited
2016
Erratum to: CXCL13–CXCR5 co-expression regulates epithelial to mesenchymal transition of breast cancer cells during lymph node metastasis
We investigated the expression of –CXC chemokine ligand 13 (CXCL13) and its receptor –CXC chemokine receptor 5 (CXCR5) in 98… 
Highly Cited
2013
Highly Cited
2013
Inhibition of the PI3K/AKT pathway potentiates cytotoxicity of EGFR kinase inhibitors in triple-negative breast cancer cells
Triple‐negative breast cancers (TNBCs) are known to be intrinsically resistant to inhibitors for epidermal growth factor receptor… 
Highly Cited
2011
Highly Cited
2011
Transient PI3K Inhibition Induces Apoptosis and Overcomes HGF-Mediated Resistance to EGFR-TKIs in EGFR Mutant Lung Cancer
Purpose: Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI), such as gefitinib and erlotinib, show… 
Highly Cited
2011
Highly Cited
2011
Troxerutin protects against high cholesterol-induced cognitive deficits in mice.
Recent findings suggest that neurotoxicity is the mechanism underlying the induction of neuronal insulin resistance by a high… 
Highly Cited
2011
Highly Cited
2011
Oncostatin M-enhanced vascular endothelial growth factor expression in human vascular smooth muscle cells involves PI3K-, p38 MAPK-, Erk1/2- and STAT1/STAT3-dependent pathways and is attenuated by…
The pleiotropic cytokine oncostatin M (OSM), a member of the glycoprotein (gp)130 ligand family, plays a key role in inflammation… 
Highly Cited
2010
Highly Cited
2010
Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor
Targeting the mammalian target of rapamycin (mTOR) protein is a promising strategy for cancer therapy. The mTOR kinase functions… 
Highly Cited
2010
Highly Cited
2010
Reconstitution of PTEN activity by CK2 inhibitors and interference with the PI3-K/Akt cascade counteract the antiapoptotic effect of human stromal cells in chronic lymphocytic leukemia.
Evidence suggests that tumor microenvironment is critically involved in supporting survival of chronic lymphocytic leukemia (CLL… 
Highly Cited
2009
Highly Cited
2009
Molecular pharmacology of phosphatidylinositol 3-kinase inhibition in human glioma
Gliomas are primary brain tumors with poor prognosis that exhibit frequent abnormalities in phosphatidylinositol 3-kinase (PI3… 
Highly Cited
2009
Highly Cited
2009
Effect of ZSTK474, a novel phosphatidylinositol 3-kinase inhibitor, on DNA-dependent protein kinase.
Phosphatidylinositol 3-kinase (PI3K) has been implicated in a variety of diseases including cancer. A number of PI3K inhibitors… 
Highly Cited
2008
Highly Cited
2008
Genetic or pharmaceutical blockade of p110delta phosphoinositide 3-kinase enhances IgE production.
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