PF 956980

Known as: PF-956980, PF956980 
 
National Institutes of Health

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2017
2017
Selective Downregulation of JAK2 and JAK3 by an ATP-Competitive pan-JAK Inhibitor.
PF-956980 has been used previously as a JAK3-selective chemical probe in numerous cell-based experiments. Here, we report that… (More)
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2016
2016
A sniff to chase ill humors away.
coimmunoprecipitates, they observed an association of both proteins. Pharmacologic inhibition of the JAK/STAT5 signaling pathway… (More)
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2015
2015
Effect of JAK Inhibitors on Release of CXCL9, CXCL10 and CXCL11 from Human Airway Epithelial Cells
BACKGROUND CD8+ T-cells are located in the small airways of COPD patients and may contribute to pathophysiology. CD8+ cells… (More)
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2013
2013
Inhibition of Janus kinase/signal transducer and activator of transcription (JAK/STAT) signalling pathway in rheumatoid synovial fibroblasts using small molecule compounds.
Janus kinase (JAK) inhibitors have been developed as anti-inflammatory agents and have demonstrated clinical efficacy in… (More)
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2011
2011
the microenvironment lymphocytic leukemia cells: potential for reversal of cytoprotection by cytotoxic agents induced by interleukin-4 treatment of chronic The JAK3-selective inhibitor PF-956980…
 
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2010
2010
The JAK3-selective inhibitor PF-956980 reverses the resistance to cytotoxic agents induced by interleukin-4 treatment of chronic lymphocytic leukemia cells: potential for reversal of cytoprotection…
Extensive evidence suggests that the malignant cells of chronic lymphocytic leukemia (CLL) patients are in close contact with… (More)
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2010
2010
Effects Of PF-956980, A Pan JAK Inhibitor, On Glucocorticosteroid Resistant Release Of CXCR3 Chemokines From Human bronchial Epithelial Cells
 
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2008
2008
The specificity of JAK3 kinase inhibitors.
PF-956980 is a selective inhibitor of JAK3, related in structure to CP-690550, a compound being evaluated in clinical trials for… (More)
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