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PF 956980

Known as: PF-956980, PF956980 
 
National Institutes of Health

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2 relations

Broader (2)

PyrimidinesPyrroles

Papers overview

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2018
2018
Compositions and methods for treatment of vitiligo
Methods of treating vitiligo using JAK/STAT modulating compounds are provided herein. The JAK/STAT modulating compounds may be… Expand
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2017
2017
Selective Downregulation of JAK2 and JAK3 by an ATP-Competitive pan-JAK Inhibitor.
PF-956980 has been used previously as a JAK3-selective chemical probe in numerous cell-based experiments. Here, we report that… Expand
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2016
2016
NKTL. When investigating coimmunoprecipitates, they observed an association of both proteins. Pharmacologic inhibition of the JAK/STAT5 signaling pathway led to an increased H3K27 trimethylation…
  • 2016
    • Corpus ID: 207760052
coimmunoprecipitates, they observed an association of both proteins. Pharmacologic inhibition of the JAK/STAT5 signaling pathway… Expand
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2015
2015
Effect of JAK Inhibitors on Release of CXCL9, CXCL10 and CXCL11 from Human Airway Epithelial Cells
Background CD8+ T-cells are located in the small airways of COPD patients and may contribute to pathophysiology. CD8+ cells… Expand
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2013
2013
Inhibition of Janus kinase/signal transducer and activator of transcription (JAK/STAT) signalling pathway in rheumatoid synovial fibroblasts using small molecule compounds
Janus kinase (JAK) inhibitors have been developed as anti‐inflammatory agents and have demonstrated clinical efficacy in… Expand
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2011
2011
the microenvironment lymphocytic leukemia cells: potential for reversal of cytoprotection by cytotoxic agents induced by interleukin-4 treatment of chronic The JAK3-selective inhibitor PF-956980…
 
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Highly Cited
2010
Highly Cited
2010
The JAK3-selective inhibitor PF-956980 reverses the resistance to cytotoxic agents induced by interleukin-4 treatment of chronic lymphocytic leukemia cells: potential for reversal of cytoprotection…
Extensive evidence suggests that the malignant cells of chronic lymphocytic leukemia (CLL) patients are in close contact with… Expand
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2010
2010
Effects Of PF-956980, A Pan JAK Inhibitor, On Glucocorticosteroid Resistant Release Of CXCR3 Chemokines From Human bronchial Epithelial Cells
 
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Highly Cited
2008
Highly Cited
2008
The specificity of JAK3 kinase inhibitors.
PF-956980 is a selective inhibitor of JAK3, related in structure to CP-690550, a compound being evaluated in clinical trials for… Expand
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