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PF 956980
Known as:
PF-956980
, PF956980
National Institutes of Health
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Related topics
Related topics
2 relations
Broader (2)
Pyrimidines
Pyrroles
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Compositions and methods for treatment of vitiligo
S. D. Shanler
,
E. Dick
,
Neal Stuart Walker
,
C. Powala
2018
Corpus ID: 191167189
Methods of treating vitiligo using JAK/STAT modulating compounds are provided herein. The JAK/STAT modulating compounds may be…
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2017
2017
Selective Downregulation of JAK2 and JAK3 by an ATP-Competitive pan-JAK Inhibitor.
S. D. Field
,
Jacob Arkin
,
Jing Li
,
L. Jones
ACS chemical biology
2017
Corpus ID: 26965014
PF-956980 has been used previously as a JAK3-selective chemical probe in numerous cell-based experiments. Here, we report that…
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2016
2016
NKTL. When investigating coimmunoprecipitates, they observed an association of both proteins. Pharmacologic inhibition of the JAK/STAT5 signaling pathway led to an increased H3K27 trimethylation…
2016
Corpus ID: 207760052
coimmunoprecipitates, they observed an association of both proteins. Pharmacologic inhibition of the JAK/STAT5 signaling pathway…
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2015
2015
Effect of JAK Inhibitors on Release of CXCL9, CXCL10 and CXCL11 from Human Airway Epithelial Cells
P. Fenwick
,
P. Macedo
,
I. Kilty
,
P. Barnes
,
L. Donnelly
PloS one
2015
Corpus ID: 6787483
Background CD8+ T-cells are located in the small airways of COPD patients and may contribute to pathophysiology. CD8+ cells…
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2013
2013
Inhibition of Janus kinase/signal transducer and activator of transcription (JAK/STAT) signalling pathway in rheumatoid synovial fibroblasts using small molecule compounds
K. Migita
,
Y. Izumi
,
+10 authors
S. Motokawa
Clinical and experimental immunology
2013
Corpus ID: 25158711
Janus kinase (JAK) inhibitors have been developed as anti‐inflammatory agents and have demonstrated clinical efficacy in…
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2011
2011
the microenvironment lymphocytic leukemia cells: potential for reversal of cytoprotection by cytotoxic agents induced by interleukin-4 treatment of chronic The JAK3-selective inhibitor PF-956980…
W. Lowdell
,
E. Samuel
,
+5 authors
S. Hart
2011
Corpus ID: 88888228
Highly Cited
2010
Highly Cited
2010
The JAK3-selective inhibitor PF-956980 reverses the resistance to cytotoxic agents induced by interleukin-4 treatment of chronic lymphocytic leukemia cells: potential for reversal of cytoprotection…
A. Steele
,
A. Prentice
,
+5 authors
R. Wickremasinghe
Blood
2010
Corpus ID: 206885290
Extensive evidence suggests that the malignant cells of chronic lymphocytic leukemia (CLL) patients are in close contact with…
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2010
2010
Effects Of PF-956980, A Pan JAK Inhibitor, On Glucocorticosteroid Resistant Release Of CXCR3 Chemokines From Human bronchial Epithelial Cells
P. Fenwick
,
I. Kilty
,
M. Yeadon
,
P. Barnes
,
L. Donnelly
ATS
2010
Corpus ID: 88440664
Highly Cited
2008
Highly Cited
2008
The specificity of JAK3 kinase inhibitors.
P. Changelian
,
D. Moshinsky
,
+11 authors
E. Kudlacz
Blood
2008
Corpus ID: 22914435
PF-956980 is a selective inhibitor of JAK3, related in structure to CP-690550, a compound being evaluated in clinical trials for…
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