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PF 956980

Known as: PF-956980, PF956980 
National Institutes of Health

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2 relations

Broader (2)

PyrimidinesPyrroles

Papers overview

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2018
2018
Compositions and methods for treatment of vitiligo
Methods of treating vitiligo using JAK/STAT modulating compounds are provided herein. The JAK/STAT modulating compounds may be… 
2017
2017
Selective Downregulation of JAK2 and JAK3 by an ATP-Competitive pan-JAK Inhibitor.
PF-956980 has been used previously as a JAK3-selective chemical probe in numerous cell-based experiments. Here, we report that… 
2016
2016
NKTL. When investigating coimmunoprecipitates, they observed an association of both proteins. Pharmacologic inhibition of the JAK/STAT5 signaling pathway led to an increased H3K27 trimethylation…
  • 2016
  • Corpus ID: 207760052
coimmunoprecipitates, they observed an association of both proteins. Pharmacologic inhibition of the JAK/STAT5 signaling pathway… 
2015
2015
Effect of JAK Inhibitors on Release of CXCL9, CXCL10 and CXCL11 from Human Airway Epithelial Cells
Background CD8+ T-cells are located in the small airways of COPD patients and may contribute to pathophysiology. CD8+ cells… 
2013
2013
Inhibition of Janus kinase/signal transducer and activator of transcription (JAK/STAT) signalling pathway in rheumatoid synovial fibroblasts using small molecule compounds
Janus kinase (JAK) inhibitors have been developed as anti‐inflammatory agents and have demonstrated clinical efficacy in… 
2011
2011
the microenvironment lymphocytic leukemia cells: potential for reversal of cytoprotection by cytotoxic agents induced by interleukin-4 treatment of chronic The JAK3-selective inhibitor PF-956980…
Highly Cited
2010
Highly Cited
2010
The JAK3-selective inhibitor PF-956980 reverses the resistance to cytotoxic agents induced by interleukin-4 treatment of chronic lymphocytic leukemia cells: potential for reversal of cytoprotection…
Extensive evidence suggests that the malignant cells of chronic lymphocytic leukemia (CLL) patients are in close contact with… 
2010
2010
Effects Of PF-956980, A Pan JAK Inhibitor, On Glucocorticosteroid Resistant Release Of CXCR3 Chemokines From Human bronchial Epithelial Cells
Highly Cited
2008
Highly Cited
2008
The specificity of JAK3 kinase inhibitors.
PF-956980 is a selective inhibitor of JAK3, related in structure to CP-690550, a compound being evaluated in clinical trials for… 
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