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PF 8380

Known as: PF-8380, PF8380 
National Institutes of Health

Papers overview

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2018
2018
Pharmacologic targeting of the ATX/LPA axis attenuates bleomycin-induced pulmonary fibrosis.
2018
2018
Development of autotaxin inhibitors: A series of zinc binding triazoles.
2018
2018
Autotaxin/lysophosphatidic acid signaling mediates obesity‐related cardiomyopathy in mice and human subjects
Obesity is associated with increased cardiovascular morbidity and mortality, but the direct signals to initiate or exaggerate… 
2018
2018
Inhibition of autotaxin alleviates inflammation and increases the expression of sodium-dependent glucose cotransporter 1 and Na+/H+ exchanger 3 in SAMP1/Fc mice.
Crohn's disease (CD) is a chronic, relapsing, inflammatory disease that is often associated with malnutrition because of… 
2017
2017
Design, synthesis, docking and biological evaluation of 4-phenyl-thiazole derivatives as autotaxin (ATX) inhibitors.
2016
2016
Fingolimod promotes peripheral nerve regeneration via modulation of lysophospholipid signaling
The lysophospholipids sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA) are pleiotropic signaling molecules with a… 
2013
2013
PF‐8380 and Closely Related Analogs: Synthesis and Structure–Activity Relationship towards Autotaxin Inhibition and Glioma Cell Viability
A series of PF‐8380 analogs, a recently developed autotaxin inhibitor, was explored. Inhibition of autotaxin by these analogs, as… 
2013
2013
Abstract 2136: Inhibition of autotaxin enhances radiosensitivity in human and murine glioblastoma cell lines.
Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC Glioblastoma multiforme (GBM), a grade IV… 
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