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PF 8380

Known as: PF-8380, PF8380 
 
National Institutes of Health

Papers overview

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2019
2019
Abstract Obesity is associated with increased cardiovascular morbidity and mortality, but the direct signals to initiate or… Expand
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2018
2018
Idiopathic pulmonary fibrosis (IPF) is a chronic fibrosing lung disease with a dismal prognosis and a largely unknown etiology… Expand
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2018
2018
Abstract Lysophosphatidic acid (LPA) is a simple biological lipid and mediates several biological functions with LPA receptors… Expand
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2018
2018
A series of inhibitors of Autotaxin (ATX) has been developed using the binding mode of known inhibitor, PF-8380, as a template… Expand
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2017
2017
The autotaxin-lysophophatidic acid (ATX-LPA) signaling pathway is involved in several human diseases such as cancer, autoimmune… Expand
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2016
2016
BackgroundThe lysophospholipids sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA) are pleiotropic signaling molecules… Expand
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2015
2015
We previously reported that i) a Western diet increased levels of unsaturated lysophosphatidic acid (LPA) in small intestine and… Expand
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2013
2013
Purpose: Glioblastoma multiforme (GBM) is an aggressive primary brain tumor that is radio-resistant and recurs despite aggressive… Expand
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2013
2013
A series of PF-8380 analogs, a recently developed autotaxin inhibitor, was explored. Inhibition of autotaxin by these analogs, as… Expand
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Highly Cited
2010
Highly Cited
2010
Autotaxin is the enzyme responsible for the production of lysophosphatidic acid (LPA) from lysophosphatidyl choline (LPC), and it… Expand
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