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Lithium treatment prevents neurocognitive deficit resulting from cranial irradiation.
It is shown that lithium treatment protects irradiated hippocampal neurons from apoptosis and improves cognitive performance of irradiated mice and is proposed as a novel therapy for prevention of deleterious neurocognitive consequences of cranial irradiation.
GSK-3β: A Bifunctional Role in Cell Death Pathways
- Keith M. Jacobs, S. Bhave, D. Ferraro, J. Jaboin, D. Hallahan, D. Thotala
- BiologyInternational journal of cell biology
- 21 May 2012
This paper is primarily focused on addressing the bifunctional or conflicting roles of GSK-3β in both the promotion of cell survival and of apoptosis.
Role of 16S ribosomal RNA methylations in translation initiation in Escherichia coli
Targeted mutations in the methyltransferase genes have revealed a connection between the rRNA modifications and the fundamental process of the initiator tRNAs selection by the ribosome.
GSK-3β inhibition promotes cell death, apoptosis, and in vivo tumor growth delay in neuroblastoma Neuro-2A cell line
- A. Dickey, S. Schleicher, K. Leahy, R. Hu, D. Hallahan, D. Thotala
- Biology, MedicineJournal of Neuro-Oncology
- 16 December 2010
In vitro results suggest that GSK-3β is a potential molecular target for the treatment of neuroblastoma and translate into delayed tumor growth in vivo using a heterotopic tumor model in nude mice treated with SB415286.
The ATF6 pathway of the ER stress response contributes to enhanced viability in glioblastoma
It is found that radiation can induce ER stress and downstream signaling associated with the ERSR, and activation of ATF6 contributes to the radiation-induced upregulation of glucose regulated protein 78 (GRP78) and NOTCH1.
Autotaxin and LPA Receptors Represent Potential Molecular Targets for the Radiosensitization of Murine Glioma through Effects on Tumor Vasculature
Mice treated with BrP-LPA and irradiation showed a tumor growth delay of 6.8 days compared to mice treated with irradiation alone indicating that inhibition of ATX and LPA receptors may significantly improve malignant glioma response to radiation therapy.
A Gamma-Knife-Enabled Mouse Model of Cerebral Single-Hemisphere Delayed Radiation Necrosis
Following GK irradiation, mice develop late time-to-onset cerebral RN histology mirroring clinical observations, and MR imaging provides reliable quantification of the necrotic volume that correlates well with histologic score.
Impact of concurrent versus adjuvant chemotherapy on the severity and duration of lymphopenia in glioma patients treated with radiation therapy
Concurrent chemotherapy appears as the dominant contributor to the severity of acute lymphopenia after RT in WHO grade II–III glioma patients, and duration of adjuvant chemotherapy appears to be the key factor to prolonged lymph Openia.
Lactobacillus rhamnosus GG protects the intestinal epithelium from radiation injury through release of lipoteichoic acid, macrophage activation and the migration of mesenchymal stem cells
LTA effectively protected the normal intestinal crypt, but not tumours in fractionated radiation regimens, by triggering a multicellular, adaptive immune signalling cascade involving macrophages and PGE2 secreting MSCs.