PEBP1 gene

BACKGROUND Diminished expression of Raf kinase inhibitor protein (RKIP), an inhibitor of the Raf signaling cascade, promotes… (More)

BACKGROUND & AIMS The Raf kinase inhibitor protein (RKIP) has been identified as a suppressor of the mitogen-activated protein… (More)

PURPOSE Raf-1 kinase inhibitor protein (RKIP) was originally identified as the first physiologic inhibitor of the Raf/mitogen… (More)

Cancer cells are more susceptible to chemotherapeutic agent-induced apoptosis than their normal counterparts. Although it has… (More)

Mutations in the Raf signaling pathway are known to play a pivotal role in the progression of malignant melanoma. In this study… (More)

Protein kinase C (PKC) regulates activation of the Raf-1 signaling cascade by growth factors, but the mechanism by which this… (More)

Feedback inhibition is a fundamental principle in signal transduction allowing rapid adaptation to different stimuli. In… (More)

The Raf kinase inhibitor protein (RKIP) acts as a negative regulator of the mitogen-activated protein (MAP) kinase (MAPK) cascade… (More)

We have recently identified the Raf kinase inhibitor protein (RKIP) as a physiological endogenous inhibitor of the Raf-1/MEK… (More)

Raf-1 phosphorylates and activates MEK-1, a kinase that activates the extracellular signal regulated kinases (ERK). This kinase… (More)