K. Boekelheide

Publications223
h-index58
Citations12,011
Highly Influential Citations448
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NTP Center for the Evaluation of Risks to Human Reproduction: phthalates expert panel report on the reproductive and developmental toxicity of di(2-ethylhexyl) phthalate.
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NTP-CERHR expert panel report on the reproductive and developmental toxicity of bisphenol A.
TLDR
This research presents a meta-analyses of the immune system’s response to exposure to radiation and shows clear patterns of decline in the immune systems of men and women aged 65 and over.
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The Fas system is a key regulator of germ cell apoptosis in the testis.
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The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis.
TLDR
No evidence for failure of gene silencing is found in sir2alpha null animals, suggesting that either SIR2alpha has a different role in mammals than it does in Saccharomyces cerevisiae or that its role is confined to a small subset of mammalian genes.
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The Mammalian SIR2α Protein Has a Role in Embryogenesis and Gametogenesis
TLDR
No evidence for failure of gene silencing is found in sir2α null animals, suggesting that either SIR2α has a different role in mammals than it does in Saccharomyces cerevisiae or that its role in genesilencing in confined to a small subset of mammalian genes.
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The Fas system, a regulator of testicular germ cell apoptosis, is differentially up-regulated in Sertoli cell versus germ cell injury of the testis.
TLDR
Data support the following hypotheses: 1) up-regulation of Fas is a common and critical step for initiating germ cell death in vivo; and 2) if Sertoli cells are injured, SERToli cells up-regulate FasL to eliminate Fas-positive germ cells, which cannot be supported adequately.
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Mono-(2-ethylhexyl) phthalate rapidly alters both Sertoli cell vimentin filaments and germ cell apoptosis in young rat testes.
TLDR
The early collapse in Sertoli cell vimentin filaments and the concurrent decrease in germ cell apoptosis suggests that MEHP engenders Sertolis cell dysfunction resulting in the disruption of the physiological mechanism of germ cell suicides.
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NTP Center for the Evaluation of Risks to Human Reproduction: phthalates expert panel report on the reproductive and developmental toxicity of di-n-octyl phthalate.
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NTP-CERHR Expert Panel Update on the Reproductive and Developmental Toxicity of di(2-ethylhexyl) phthalate.
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Spermiogenesis is impaired in mice bearing a targeted mutation in the protein phosphatase 1cgamma gene.
TLDR
Type 1 protein phosphatases (PP1) are involved in diverse cellular activities, ranging from glycogen metabolism to chromatin structure modification, mitosis, and meiosis, and defects in meiosis were inferred from the presence of polyploid spermatids.
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